不同移植方法IVF—ET后异位妊娠相关因素分析

Analysis of the Related Factors of Ectopic Pregnancy after IVF-ET

【目的】探讨不同移植方法体外受精-胚胎移植（IVF-ET）后异位妊娠相关因素。【方法】收集2006年9月至2008年12月（常规移植推注方法，A组）与2009年1月至2012年6月（改良移植推注方法，B组）接受IVF-ET获得临床妊娠患者的临床资料，比较不同移植推注方法的异位妊娠率，分析异位妊娠的影响因素。【结果】B组异位妊娠率（2．69％）较A组（7．84％）显著性降低（P〈0．01）；改良移植推注方法（OR=0．428，P〈0．01）、HCG时子宫内膜厚度≥8mm（OR=0．521，P〈0．01）是降低IVpET后异位妊娠的独立保护因素。【结论】在一定程度上改进移植推注方法和增加HCG日子宫内膜厚度可明显降低IVF-ET后异位妊娠率。

[Objective]To explore the related factors of ectopic pregnancy after in vitro fertilization and embryo transfer （IVF-ET）. [Methods] Clinical data of patients receiving routine IVF-ET（group A） from Sept. 2006 to Dec. 2008 and patients receiving the modified IVF ET（group B） from Jan. 2009 to June 2012 were collected. Ectopic pregnancy rate of different embryo transfer methods was compared. The related factors of ectopic pregnancy were analyzed. [Results]Compared with group A, ectopie pregnancy rate in group B was markedly decreased（7.84% vs. 2. 69%）（ P 〈0.01）. The modified embryo transfer method（OR=0. 428, P 〈0.01） and HCG endometrial thickness（OR=0. 521, P d0.01） were the independent pro teetive factors to decrease ectopic pregnancy rate after IVF-ET. [Conclusion]To a certain extent, improving embryo transfer method and increasing endometrial thickness on HCG day can obviously decrease ectopic pregnancy rate after IVF-ET.