重组人脑利钠肽治疗急性心肌梗死并发心功能衰竭疗效观察

Efficacy of Recombinant Brain Natriuretic Peptide for the Treatment of Patients with Acute Myocardial Infarction Complicated by Heart Failure

【目的】观察重组人脑利钠肽（rhlBNP）治疗急性心肌梗死（AMI）并发心力衰竭的疗效。【方法】50例AMI合并心力衰竭患者随机分为两组，观察组25例在常规治疗的基础上加用rh_BNP，对照组给予常规治疗，观察治疗前后两组患者临床疗效、尿量、N末端B型利钠肽原（NT—proBNP）等指标变化及心功能改善情况。【结果】治疗后观察组的总有效率显著优于对照组，且两组相比较差异有显著性（84％VS68％，P〈0．01），观察组及对照组通过治疗后，临床观察指标均有明显好转，而观察组较对照组改善更为显著。【结论】与传统药物治疗相比，rhBNP能明显改善AMI后心力衰竭患者的心功能，且不增加副作用。

[Objective]To observe the efficacy of recombinant brain natriuretic peptide（rh-BNP） for the treatment of patients with acute myocardial infarction（AMI） complicated by heart failure. [MethodslA total of 50 AMI patients complicated by heart failure were randomly divided into two groups. The observation group was additionally treated with rh-BNP based on the conventional therapy, while the control group received the routine therapy. Clinical efficacy, the change of urine volume and NT-prot3NP and the improvement of cardiac function were observed before and after treatment. [ResultslAfter treatment, the total effective rate of obser- vation group was obviously better than that of control group, and there was significantly difference between two groups（ P d0. 01）. After treatment, clinical observation indicators in two groups were obviously im- proved, but the improvement of observation group was more significant than that of control group. [Conclusion] Compared with traditional drug therapy, rh-BNP can obviously improve cardiac function of patients with heart failure after AMI and not increase the side effect.