适应卡尔曼滤波分光光度法同时测定增效联磺胶囊中各组分的含量

Simultaneous Determination of Contents of Three Components in Enhanced Sulfisomezol Compound Capsules by Adaptive Kalman Filtering Spectrophotometry

Rutan等将测量误差权重系数的适应估计值与平方根卡尔曼滤波算法相结合,提出了适应卡尔曼滤波法,本文以增效联磺胶囊为例,分别采用卡尔曼滤波法及适应卡尔曼滤波法测定其中各组分的含量,结果表明,适应卡尔曼滤波法稍好于常规卡尔曼滤波法。

Adaptive Kalman Filtering Spectrophotometry is developed for simultaneous determination of contents of sulfisomezol(SMZ), trimethoprim(TMP) and sulfadiazine(SD) contained in enhaced sulfisomezol compound capsules. The average recoveries(%) were 99. 8, 99. 9 and 100. 0 respectively. The variation coefficients (%) are 1. 5, 1. 7 and 1. 1 respectively. The results of Adaptive Kalman Filter were slightly better than those of original Kalman Filter. Adaptive Kalman Filter may provide a new approach to determine the concentrations from overlapped spectral data without any preliminary chemical separation.