2型糖尿病患者干眼症发生情况及相关因素探讨

Related factors analysis of type 2 diabetic patients with dry eye

目的:分析2型糖尿病患者并发干眼症情况及相关影响因素。方法:选取45例90眼2型糖尿病患者和40例80眼非糖尿病患者为研究对象,分析其泪膜破裂时间、基础泪液分泌试验以及角膜荧光素染色指标间的差异,并分析其相关因素。结果:观察组患者平均泪膜破裂时间为6.23±2.36s,显著短于对照组;泪液分泌试验滤纸条平均浸润长度为8.65±3.82mm,显著低于对照组;角膜荧光素染色评分为1.89±1.31分,显著高于对照组;干眼症发病率达58%,显著高于对照组,差异均具有统计学意义(P<O,05)。Logistic多因素分析显示泪液基础分泌量和泪膜破裂时间为2型糖尿病患者合并干眼症重要的危险因素。结论:2型糖尿病患者泪膜破裂时间缩短、基础泪液分泌值减少以及角膜荧光素染色评分升高。泪液基础分泌量和泪膜破裂时间为2型糖尿病患者合并干眼症重要的危险因素。

AIM： To analyze dry eye conditions of type 2 diabetes and its related factors. METHODS： Totally 45 patients （ 90 eyes ） with type 2 diabetes and 40 patients （80 eyes） non-diabetic patients were chosen for this study. Tear film break-up time, Schirmer test, and corneal fluorescein staining differences between indicators and its related factors were analyzed.RESULTS：In diabetes group, the mean tear film break-up time was 6.23±2.36s, significantly shorter than that of the control group; Schirmer infiltration experiments average length of filter strips was 8.65 ±3.82mm, significantly lower than that of the control group; corneal fluorescein staining score was 1.89 ± 1.31points, significantly higher.The incidence rate of dry eye was 58%, was significantly higher, the difference had statistically significant （P〈0.05）.The results of Logistic Multivariate analysis showed that basal secretion of tear volume and tear film break-up time were risk factors for type 2 diabetic patients with dry eye. CONCLUSION：In type 2 diabetes patients, the tear film breakup time is shortened, and the basal tear secretion is decreased corneal fluorescein staining score increased. Basal secretion of tear volume and tear film break-up time was risk factors for type 2 diabetic patients with dry eye.