LASIK术后黄斑区视网膜厚度变化的临床研究

Clinical study of changes on macular retinal thickness after LASIK in myopia

目的:探讨准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)后黄斑部视网膜厚度的变化。方法:随机抽取LASIK手术的近视眼患者69例138眼。利用光学相干断层扫描(optical coherence tomography,OCT)对所有患者术前及术后1d;1wk;1,3,6mo的黄斑部视网膜进行检查,分别测量以黄斑中心凹为中心直径0.5mm区域、直径1.5mm区域及直径3mm区域的上方、鼻侧、下方、颞侧9个区域的视网膜平均厚度及容积。结果:以黄斑中心凹为中心直径1.5mm内(A1,A2,A3,A4)术后1d;1wk的视网膜厚度及容积均低于术前,术后1,3,6mo同术前比较无明显差异。以黄斑中心凹为中心直径0.5mm内(A0)以及直径3mm内的区域(A5,A6,A7,A8)术后1d;1wk;1,3,6mo同术前比较无明显差异。结论:常规LASIK术后所出现的部分区域黄斑部视网膜厚度的改变是轻微可逆的。

AIM： To investigate the changes of macular retinal thickness after laser in situ keratomileusis （ LASIK ） in myopia. METHODS： Totally 138 eyes of 69 patients who underwent LASIK were recruited randomly.The average macular retinal thickness, and volume of nine zones which were the areas of 0.5mm diameter around the macular fovea, the superior, nasal lateral, anterior and bitamporal lateral of 1.5mm and 3mm diameter around from it, were measured pre-operatively and at 1 day, 1 week, 1 month, 3 and 6 months postoperatively by the use of optical coherence tomography （ OCT） . RESULTS：Compared with pre-operation, the retinal thickness and volume of 1.5mm diameter around the macular fovea areas （ A1, A2, A3, A4） was lower at 1 day, 1 week, and was no obvious difference on 1 month, 3 and 6 months after operation;the areas of 0.5mm （A0） and 3mm （ A5, A6, A7, A8 ） diameter around the macular fovea was no obvious difference at 1 day, 1 month, 3 and 6 months. CONCIUSION： The changes on part of macular retinal thickness are mild reversible in LASIK surgery.