PARP-1和p53在三阴性乳腺癌中表达的相关性及临床意义

The expression of PARP-1 and p53 in triple negative breast cancer and its clinical significance

目的:探讨PARP-1和p53在三阴性乳腺癌中表达的相关性及临床意义。方法:采用免疫组织化学方法检测85例三阴性乳腺癌中PARP-1和p53的表达,并进一步分析PARP-1和p53表达的相关性及PARP-1的表达与患者临床病理参数之间的关系。结果:PARP-1在三阴性乳腺癌中的过表达率为61.18%(52/85),p53的阳性表达率为65.88%(56/85),PARP-1的表达与p53的表达具有显著相关性(P<0.05)。PARP-1与p53共表达的患者生存时间显著短于非共表达的患者(P<0.05)。在三阴性乳腺癌中,PARP-1的表达与患者的TNM分期(P<0.05)、淋巴结转移状态(P<0.05)密切相关,但与患者年龄、肿瘤组织学分化程度无显著关系(P>0.05)。术后生存时间也显示PARP-1阳性表达的患者明显短于阴性表达的患者(P<0.05)。结论:PARP-1和p53在三阴性乳腺癌中的表达具有相关性,且PARP-1和p53共表达与乳腺癌患者的不良预后密切相关。

Objective ：To explore the expression of PARP - 1 and p53 and its clinical significance in triple negative breast cancer （TNBC）. Methods： Immunohistochemical assay was performed to detect the expression of PARP - 1 and p53 in 85 cases of TNBC. Furthermore,we analyzed the expressive correlation of PARP- 1 and p53 ,and the relationship between PARP - 1 expression and clinicopathological factors. Resolts ： The over - expression rate of PARP - 1 was 61.18% （52/85） in TNBC,and the positive expression rate of p53 was 65.88% （56/85）. There was significant correlation between PARP - 1 and io53 expression （ P 〈 0.05 ）. The patients with co - expression of PARP - 1 and p53 had a shorter survival time than the patients without（ P 〈 0.05 ）. There also had closely relationship between PARP - 1 expression and TNM stages （ including the status of lymphatic metastasis, P 〈 0.05 ）. However, there was no correlation between PARP - 1 expression and age, histological differentiation, P 〉 0.05. The postoperative survival pe- riod of patients with PARP - 1 positive expression was shorter than that of patients with PARP - 1 negative expression （P 〈0.05 ）. Conclusion：There has a correlation between PARP- 1 and p53 expression in TNBC, and the co -expression of PARP - 1 and p53 was associated with poor prognosis of TNBC patients.