摘要
目的:探讨食管鳞癌组织(ESCC)中p53和HER-2的表达及其与临床病理及生存时间之间的相关性。方法:免疫组织化学法检测102例已行手术切除的食管鳞癌组织中p53和HER-2的表达水平,分析比较p53及HER-2两者的相关性,及两者和临床病理之间的关系,比较p53和HER-2的表达水平和患者平均生存时间之间的相关性。结果:102例ESCC组织中56例癌组织的p53表达阳性(54.90%)。其阳性表达与患者性别、年龄、病变长度、部位、临床TNM分期、癌细胞分化程度、区域淋巴结转移未呈现相关性(P>0.05);22例患者癌组织HER-2表达阳性(21.57%),其阳性与组织分化程度、区域淋巴结转移正相关(P<0.05);与患者的年龄、性别、病变部位、病变长度及临床TNM分期未见有相关性(P>0.05)。HER-2与p53两者的表达显著正相关(r=0.343,P=0.01)。通过随访,HER-2表达阳性组生存时间与阴性组比较有显著差异,前者生存时间较后者短(37.37±1.75个月vs 44.71±1.37个月,P<0.05);p53表达阳性组与阴性组未见显著性差异(40.37±0.76个月vs 44.11±1.15个月,P>0.05)。结论:p53与HER-2蛋白在ESCC中均过表达,HER-2蛋白过表达可能提示预后不良,p53过表达与预后无相关性,两者可能在ESCC的发生、发展中存在相关性。
Objective ： To study the expression of p53 and HER - 2 oncogene in esophageal squamous cell carcino- ma（ESCC） ,and explore the relation between the clinical and pathological characteristics and survival time. Methods：By immunohistochemical method, we detected p53 and HER- 2 oncogene expression in 102 cases of ESCC tissue after surgical resection, and investigated the correlation between p53 and HER -2, and the clinicopathologie characteristics. Results：p53 expressed positively（54.90% ） in ESCC tissue, and there was no correlation in ESCC differentiation degree, gender, age, disease length,location and TNM stage, tissue cell differentiation degree,lymph node metastasis （P 〉 0.05）. The expression of HER -2 was 21.57%. Patients with ESCC with positive expression had shorter survival time than those with negative expression on HER - 2 （37.37 ±1.75months vs 44.71 ±1.37months,P 〈 0.05 ） , while the expression of p53 did not differed （ 40.37 ±0.76months vs 44. 11 ±1.15months,P 〉 0. （15）. Conclusion：p53 and HER -2 overexpressed in ESCC, p53 plays an important role in the development of ESCC. Cases with positive HER - 2 expression have shorter survival time than those with negative HER - 2 expression, p53 positive and negative groups did not see significant difference. The expression of p53 and HER- 2 gene has close correlation.
出处
《现代肿瘤医学》
CAS
2014年第1期98-101,共4页
Journal of Modern Oncology
