三维适形放疗联合S-1治疗局部晚期胰腺癌临床观察

Effect of three dimensional-conformal radiotherapy combined with S-1 to treat locally advanced pancreatic cancer

目的:探讨三维适形放疗联合S-1治疗局部晚期胰腺癌的临床疗效。方法:36例患者随机分为放化疗组与单纯放疗组。放疗组给予5个三维适形放疗野等中心照射,剂量为50Gy/(25f·5w),放化疗组患者的放疗射野及剂量同放疗组,同时自放疗的第一天起口服S-1,剂量60mg/m2,2次/d,第1至28天,休14天重复,每例患者接受2周期S-1化疗。观察疗效及不良反应。结果:放化疗组有效率高于单放组(66.7%vs44.4%),放化疗组1年生存率高于单放组(45%vs 20%),不良反应放化疗组稍高于单放组,患者可以耐受。结论:三维适形放疗联合S-1是局部晚期胰腺癌较为理想的方法,疗效优于单纯放疗组。

Objective：To study the effect of three dimensional - conformal radiotherapy combined with S - 1 in treating locally advanced pancreatic cancer. Methods ：All 36 patients with locally advanced pancreatic cancer were divided into 2 groups, 18 patients received three dimensional -conformal radiotherapy combined with S -1,18 patients received only three dimensional - conformal radiotherapy. Radiotherapy was delivered by 6MV - X ray. Elected sinergy clinic accerator,5 coplanar radiation fields was made by Xio 3 - D three dimensional treat planning system. Concurrent chemoradiotherapy was given at the first day S - 1 60mg/d 1 - 28 of 42 - day cycle, at least two cycles. Results： The overall effective rate was 66.7% of chemo -radiotherapy. The 1 -year survival rate was 45%. Conclusion ：The dimensional - eonformal radiotherapy combined with S - 1 had higher effective rate and 1 - year survival rate than on- ly radiotherapy to treat locally advanced pancreatic cancer.