宫颈毛玻璃样细胞癌1例报告并文献复习

Glassy cell carcinoma:a case report and literature review

目的:研究宫颈毛玻璃细胞癌的临床表现、临床病理特征、鉴别诊断及其预后。方法:对1例宫颈毛玻璃细胞癌(GCC)进行大体、光镜及免疫组织化学观察并结合文献复习。结果:镜下见:细胞呈簇状、小片状分布,细胞界限清楚,肿瘤细胞呈典型毛玻璃样特点,胞质丰富,内含大量嗜酸性颗粒,核染色质细腻,核仁嗜酸性,较大且突出,核分裂象可见,间质中可见大量嗜酸性粒细胞和浆细胞浸润。免疫组化:CK5/6(+)、CK7(+)、CK8/18(+)、p63(+)、Ki-67阳性率约80%。结论:宫颈GCC是宫颈腺鳞癌的特殊亚型,具有独特的细胞学和组织形态特点,表达腺上皮及鳞状上皮标志物。

Objective：To explore the clinical manifestations,clinical pathological characteristics,differential diagnosis and prognosis of glassy cell carcinoma（GCC）. Methods ：A case of GCC was analyzed grossly,light microscopi- cally and immunohistochemically and related literatures were reviewed. Results：Morphologically, the tumors consisted of clusters of tumor cells with distinct cell bounders, a large amount of eosinophilic granules in the cytoplasm imparting ground glass appearance, and prominent nucleoli. Nuclear enlargement and multinucleation were frequently noted. Numerous eosinophils and plasma cells were present in the stroma. Immunohistochemistry resuhs：CK5/6 （ ＋ ） , CK7 （ ＋ ） ,CK8/18（ ＋ ） ,p63（ ＋ ）. The proliferation index of Ki -67 was 80%. Conclusion：GCC is a distinct variant of adenosquamous carcinoma of the cervix with high proliferation index and expression of markers of both squamous cell carcinoma and adenocarcinoma. The tumor has characteristic cytological and histological features.