磁共振弥散张量成像定量分析正常成人_4、L_5、S_1神经根

Quantitative analysis of L_4,L_5,S_1 nerve roots of normal adults with magnetic resonance diffusion tensor imaging

目的:探讨正常成人L4、L5、S1神经根磁共振弥散张量成像(diffusion tensor imaging,DTI)及神经纤维束示踪成像(diffusion tensor tractography,DTT)的可行性及量化特征。方法:20名健康志愿者接受3.0 T飞利浦磁共振检查机DTI及DTT,测定L4、L5、S1神经根各向异性系数(fractional anisotropy,FA)、表观弥散系数(apparent diffusion coefficient,ADC)并进行双侧神经根及同侧上下神经根弥散数值的比较。结果:20名健康志愿者DTI及DTT均成功,DTT图可以清晰显示L4、L5、S1神经根。测量L4、L5、S1神经根FA及ADC的均值分别为0.395±0.146和(1.288±0.116)mm2/s,0.390±0.122和(1.297±0.087)mm2/s,0.387±0.117和(1.294±0.132)mm2/s。双侧神经根及同侧上下神经根弥散参数无差异(P>0.05)。结论:正常成人L4、L5、S1神经根DTI及DTT是可行的,能够显示神经根走行并进行量化分析,为研究神经根病变提供了影像学信息。

Objective： To investigate the feasibility of diffusion tensor imaging （DTI） and diffusion tensor tractography （DTF） on L4,L5,S1 nerve roots of normal adults and to analyze the diffusion parameters. Methods：DTI and DTTwere performed on 20 healthy volun- teers at Philips Achieva 3.0 T magnetic resonance scanner. Fractional anisotropy（FA） and apparent diffusion coefficient（ADC） of the nerve roots （L4, Ls, SO were measured and results of DTI and DTr were obtained. Results：Twenty volunteers were successful recon- structed by DTI and DTF. L4,L5,S1 nerve roots could show clearly on the DTT map. Average FA and ADC values of healthy volunteers （L4,L5,S1 were 0.395 ±0.146 and （1.288 ±0.116） mm2/s,0.390 ±0.122 and （1.297 ±0.087） mm2/s,0.387 ±0.117 and （1.294 ±0.132） mm2/s,respeetively. There was no significant difference of diffusion tensor parameters between bilateral nerve roots（P〉0.05） and between upper and lower nerve roots （P〉0.05）. Cottclusions：DTI and DTr on L4,L5,S1 nerve roots of normal adults are feasible. DTI and DTY can show the architecture of the nerve roots and provide quantitative information for further research of the nerve root diseases.