硫酸镁治疗子痫前期患者的临床疗效分析及其对血浆纤维蛋白原浓度的影响

MAGNESIUM SULFATE THERAPY IN PATIENTS WITH PRE- ECLAMPSIA AND ITS IMPACT ON THE CLINICAL EFFICACY OF PLASMA FIBRIINOGEN CONCENTRATION

目的:探索硫酸镁对子痫前期患者的临床疗效及其对血浆纤维蛋白原浓度的影响。方法:研究对象为82例妊娠子痫前期子痫患者,随机分为硫酸镁组和对照组,全部患者入院确诊后,严密观察,嘱咐患者注意良好饮食和充足的休息,并进行一般性镇静治疗,硫酸镁组患者在此治疗基础上,加入硫酸镁治疗。治疗期间,对两组孕产妇及胎儿情况进行监测,观察孕妇血压控制情况。血浆纤维蛋白原检测,抽出的最初2mL血液,3000 r/min离心15min,取血浆待检测纤维蛋白原。结果:硫酸镁组与对照组患者,给予相应的治疗后,硫酸镁组患者收缩压与舒张压均显著低于对照组患者,差异有统计学意义(P<0.05)。治疗后,硫酸镁组患者血浆纤维蛋白原含量(4.13±0.65 g/L)显著低于对照组患者(5.24±0.89 g/L),且差异具有统计学意义(P<0.05)。结论:硫酸镁可以有效控制子痫前期患者血压,并降低血浆纤维蛋白原水平。

Objective： To explore the magnesium sulfate for pre - eclampsia and its impact on the clinical efficacy of plasma fibrino- gen concentration. Methods：The subjects were 82 cases of preeclampsia and eclampsia of pregnancy were randomly divided into magne- sium group （ n = 41 ） and control group （ n = 41 ）. All patients admitted to hospital after diagnosis were closely observed, asked were to have good diet and plenty of rest, and a general sedation. The patients in the magnesium group on the basis of this therapy , magne- sium sulfate therapy. During treatment, maternal and fetal monitoring, pregnant women blood pressure were observed between the two groups . Plasma fibrinogen test, taken the initial 2mL blood , 3000 r/min centrifugation 15min, the plasma fibrinogen were detected. Results：Magnesium sulfate group and the control group were given the appropriate treatment, systolic and diastolic blood pressure in patients with magnesium group as significantly lower than that of the control group of patients, the difference was statistically significant （P 〈0. 05）. After treatment, the magnesium sulfate group, plasma fibrinogen levels （4. 13 ± 0. 65 g / L） were significantly lower than control patients （5.24 ± O. 89 g / L）, and the difference was statistically significant （P 〈 O. 05）. Conclusion：Magnesium sul- fate can effectively control blood pressure of the patients with preeclampsia and reduc plasma fibrinogen levels.