2-甲基-4-巯基呋喃衍生物的制备

Preparation of 2-Methyl-4-mercaptofuran Derivatives

β-巯基呋喃衍生物广泛应用于食品、医药和化妆品工业,2-甲基-3-巯基呋喃衍生物的制备文献报道较多,Hase,Gawa等由4-羰基-2-戊烯醛的缩醛与硫醇进行亲核加成、关环制得了2-甲基-4-巯基呋喃衍生物.我们由4-羰基-2-戊烯醛与硫代乙酸进行自由基加成、关环等步骤制得了12种标题化合物,其中Ⅰa～c、Ⅱ a、Ⅱc和Ⅱc～1一为新化合物。

This paper reports the preparation of twelve 2-methyl- 4-mercaptofuran derivatives with 2-methyl-4-thioacetyl furan as raw material. The compounds Ⅰa-e,Ⅱa,Ⅱc and Ⅱe-f, are new compounds.