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抗中性粒细胞胞质抗体相关性血管炎免疫学研究进展 被引量：1

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摘要 抗中性粒细胞胞质抗体（anti—neutrophilcytoplasmicautoantibodies，ANCA）相关性小血管炎，是一组以小血管壁的炎症及纤维素样坏死为主要表现的自身免疫性疾病，主要特点是血清中存在针对蛋白酶3或髓过氧化物酶（myeloperoxidase，MPO）的抗中性粒细胞胞质抗体。主要包括肉芽肿性多血管炎即韦格纳肉芽肿病，显微镜下多血管炎和嗜酸细胞性肉芽肿性多血管炎即变应性肉芽肿性血管炎。发病机制尚未完全阐明，目前认为与遗传、环境、免疫等多因素有关，其中免疫异常在ANCA相关性小血管炎的发病中起着重要作用。
作者 赵雯 代华平 王辰
机构地区 北京呼吸疾病研究所北京市呼吸与肺循环疾病重点实验室首都医科大学附属北京朝阳医院呼吸与危重症医学科 卫生部北京医院呼吸病学研究中心
出处 《中华医学杂志》 CAS CSCD 北大核心 2013年第48期3879-3881,共3页 National Medical Journal of China
基金 国家自然科学基金（81270123）
关键词 ANCA相关性小血管炎 抗中性粒细胞胞质抗体 免疫学 变应性肉芽肿性血管炎 显微镜下多血管炎 自身免疫性疾病 韦格纳肉芽肿病 髓过氧化物酶
分类号 R593 [医药卫生—内科学]
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参考文献30

  • 1Stambe C,Nikolic-Paterson D J,Hill PA. p38 Mitogenactivated protein kinase activation and cell localization in human glomerulonephritis:correlation with renal injury[J].{H}Journal of the American Society of Nephrology,2004.326-336.
  • 2Hao J,Meng LQ,Xu PC. p38MAPK,ERK and PI3K signaling pathways are involved in C5a-primed neutrophils for ANCA-mediated activation[J].PLoS One,2012.e38317.
  • 3Sheryanna A,Bhangal G,Mcdaid J. Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1 beta or IL-6[J].{H}Journal of the American Society of Nephrology,2007.1167-1179.
  • 4Kain R,Exner M,Brandes R. Molecular mimicry in pauciimmune focal necrotizing glomerulonephritis[J].{H}Nature Medicine,2008.1088-1096.
  • 5于峰;赵明辉;章友康.抗内皮细胞抗体及其靶抗原在抗中性粒细胞胞质抗体相关小血管炎中的意义[J]{H}中华肾脏病杂志,2004(z1):11-15.
  • 6Kessenbrock K,Krumbholz M,Sch(o)nermarck U. Netting neutrophils in autoimmune small-vessel vasculitis[J].{H}Nature Medicine,2009.623-625.
  • 7邢广群,李敏,魏志敏.中性粒细胞细胞外网络在ANCA相关性小血管炎患者肾组织中的表达及意义[J].中国中西医结合肾病杂志,2012,13(11):960-962. 被引量：5
  • 8Komocsi A,Lamprecht P,Csernok E. Peripheral blood and granuloma CD4 + CD28-T cells are a major source of interferon-γ and tumor necrosis factor-α in Wegener's granulomatosis[J].{H}AMERICAN JOURNAL OF PATHOLOGY,2002.1717-1724.
  • 9Weidner S,Carl M,Riess R. Histologic analysis of renal leukocyte infiltration in antineutrophil cytoplasmic antibodyassociated vasculitis:importance of monocyte and neutrophil infiltration in tissue damage[J].{H}ARTHRITIS AND RHEUMATISM,2004.3651-3657.
  • 10Capraru D,Müller A,Csemok E. Expansion of circulating NKG2D + effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis[J].{H}CLINICAL IMMUNOLOGY,2008.144-150.

二级参考文献25

  • 1吴长有.Th17细胞:一种新的效应CD4^+T细胞亚群[J].细胞与分子免疫学杂志,2006,22(6):695-697. 被引量：36
  • 2Krakowski M,Owens T. Intefferon-γconfers resistance to experimental allergic encephalomyelitis. Eur. J Immunol. 1996,26(7 ) : 1641-1646,
  • 3Tato CM, O' Shea JJ. What does it mean to be just 177 Nature,2006, 441( 11 ) :166-168.
  • 4Aggarwal S, Ghilardi N, Xie MH, et al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem, 2003, 278(3), 1910-1914
  • 5Weaver CT, Harrington LE, Mangan PR, et al. Th17 : Aneffector CD4T cell lineage with regulatory T cell Ties. Immunity, 2006,24 (4) : 677- 688.
  • 6Veldhoen M, Hocking R J, Atkins C J, et al . TGF-βin the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17- producing T cells, Immunity ,2006,24 ( 2 ) : 179-189.
  • 7Manga PR, Hanington LE, O' Quinin DB, et al. Transforming growth factor-βinduces development of the T ( H ) 17 lineage. Nature, 2006 ( 7090 ) ,441:231-234
  • 8Batten M, Li J, Yi S, et al. Interleukin 27 limits autoimmune encepha- lomyelitis by suppressing the development of . Interleukin 17-producing T cells. Nature Immunol,2006,7( 9 ) :929-936
  • 9Bettelli E,Oukka M, Kuchmo VK. TH-17 cells in the circle of immunity and autoimmunity. Nature Immunology ,2007,8 (4) :345-350
  • 10Ivanov Ⅱ, Mckcnzie BS, Zhou L, et al. The orphan nuclear receptor RORrt directs the differentiation program of proinflammatory IL-17 + T helper cells. Cell ,2006,126(6), 1121-1133.

共引文献14

同被引文献10

  • 1Jennette JC, Falk RJ, Bacon PA, et al. 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides [ J ]. Arthritis Rheum, 2013, 65 ( 1 ) : 1-11.
  • 2Guillevin L, Pagnoux C, Seror R, et al. The Five-Factor Score revisited : assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group cohort [J]. Medicine, 2011,90 (1) :19-27.
  • 3Sinieo RA, Di Toma L, Radice A. Renal involvement in anti- neutrophil cytoplasmic autoantibody associated vaseulitis [ J ]. Autoimmun Rev, 2013, 12 (4) :477- 482.
  • 4Churg SA, Seo P. Microscopic polyangiitis[ J]. Rheum Dis Clin North Am, 2010, 36(3) :545-558.
  • 5Collins CE, Quismorio FP. Pulmonary involvement in microscopic polyangiitis[ J]. Curr Opin Pulm Med, 2005, 11 (5) :447-451.
  • 6Zhang W, Zhou G, Shi Q, et al. Clinical analysis of nervous system involvement in ANCA-associated systemic vasculitides[ J]. Clin Exp Rheumatol, 2009, 27 ( 1 Suppl 52 ) : S65-S69.
  • 7Koike H, Sobue G. Clinicopathological features of neuropathy in anti-neutrophil cytoplasmic antibody-associated vasculitis [ J ]. Clin Exp Nephrol, 2013, 17(5) :683-685.
  • 8Suppiah R, Hadden R, Batra R, et al. Peripheral neuropathy in ANCA-associated vasculitis : outcomes from the European Vasculitis Study Group trials[J]. Rheumatology, 2011,50(12) : 2214-2222.
  • 9显微镜下多血管炎诊断及治疗指南[J].中华风湿病学杂志,2011,15(4):259-261. 被引量：62
  • 10林森,张文.抗中性粒细胞胞浆抗体相关性血管炎神经损害的病理和临床特点[J].中华临床免疫和变态反应杂志,2013,7(3):282-286. 被引量：13

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中华医学杂志
2013年 第48期

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