妊娠糖尿病患者血清高敏C反应蛋白的测定及临床意义

The Determination and Significance of Serum High-sensitivity CRP in Gestational Diabetes Patients

目的:探讨高敏C-反应蛋白(hs-CRP)对早期妊娠糖尿病(GDM)诊断的临床意义。方法:回顾性分析我院2008年1月至2012年1月收治入院的孕24-28周孕妇行葡萄糖筛查试验(GCT),GCT异常孕妇行糖耐量(75g OGTT)筛查,用高敏感干化学微粒增强型免疫浊度法检测GCT正常孕妇组(100例)和GCT异常孕妇组(100例)的hs-CRP水平。结果:GCT正常孕妇hs-CRP阳性率为6.0%,GCT异常孕妇组hs-CRP阳性率为51.0%,GCT正常与异常两组hs-CRP水平经秩和检验,存在显著性差异(P<0.05)。100例GCT异常孕妇根据葡萄糖耐量试验(OGTT)诊断,妊娠糖尿病(GDM)20例,葡萄糖代谢耐受不良(IGT)20例,其中GDM和IGT孕妇hs-CRP高水平浓度(>10mg/L)阳性率高于OGTT正常孕妇。GDM、IGT组和OGTT正常组hs-CRP阳性率各为55.0%(11/20)、50.0%(10/20)和50%(30/60)。结论:高敏C-反应蛋白(hs-CRP)参与了早期妊娠糖尿病(GDM)的发生发展,检测早期孕妇高敏CRP,对妊娠糖尿病的预防与控制具有十分重要的意义。

Objective：To investigate the clinical significance of high-sensitivity C-reactive protein （ hs-CRP） in diagnosis of early gestational diabetes mellitus （ GDM） .Method：Pregnant woman with in 24 to 28 gestational weeks in our hospital from January 2008 to January 2012 were given glucose screening test （GCT）, and the pregnant women with abnormal GCT was given glucose tolerance screening （75g OGTT）, the hs-CRP levels of pregnant women in normal GCT group （ 100 cases ） and abnormal GCT group （ 100 ca-ses） were detected by highly sensitive dry chemical particles enhanced immune nephelometry.Result：The positive rate of hs-CRP in normal GCT group and abnormal GCT group was 6 .0% and 51 .0%, the differ-ence between two groups was significant （ P〈0 .05 ）;100 cases of pregnant women with abnormal GCT was diagnosed with GDM in 20 cases and IGT in 20 cases, hs-CRP positive rate（〉10mg /L） of GDM and IGT patients was higher than that in pregnant women with normal OGTT.Conclusion：It＇s important for hs-CRP participate in early occurrence and development of GDM to prevent and control gestational diabetes.