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CpG-ODNs疫苗佐剂的研究进展 被引量：3

Progress in research on CpG-ODNs as vaccine adjuvants
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摘要 CpG寡聚脱氧核苷酸(CpG-ODNs)是一种新型免疫增强剂,大量动物实验和临床研究表明其在感染、肿瘤和过敏等疾病的预防和治疗等领域具有良好的应用前景。到目前为止,数10种含有CpGODNs的药物和疫苗进入人体临床研究,至少有1种药物和4种疫苗已进入或完成III期临床研究。本文主要从CpG-ODNs免疫刺激活性的研究历程、CpG-ODNs免疫刺激活性的复杂性、CpG-ODNs疫苗佐剂的临床前以及临床研究等方面介绍CpG-ODNs作为人用疫苗佐剂的研究进展。 Synthetic oligodeoxynucleotides containing unmethylated CpG-dinucleotides （CpG-ODNs） are immunostimulatory in a broad spectrum of species. Extensive studies provide evidence that CpG-ODNs are effective as immunotherapeutics and vaccine adjuvants in various clinical settings. This review summarizes the progress of CpG-ODNs as vaccine adjuvants including the research history, the complexity of immunostimulatory CpG-ODNs, and the pre-clinical and clinical studies of CpG-ODNs.
作者 许洪林 杨春亭
机构地区 北京生物制品研究所
出处 《中国新药杂志》 CAS CSCD 北大核心 2014年第1期36-43,51,共9页 Chinese Journal of New Drugs
关键词 CPG基序 CpG—ODNs 疫苗佐剂 CpG motif CpG-ODNs vaccine adjuvant
分类号 R18 [医药卫生—流行病学] R979.5 [医药卫生—药品]
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共引文献32

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中国新药杂志
2014年 第1期

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