细胞色素P450对底物的选择性及催化机制

Substrate selection and catalytic mechanism of cytochrome P450

细胞色素P450酶是广泛存在的含亚铁血红素单加氧酶,参与甾类激素的合成、脂溶性维生素代谢、多不饱和脂肪酸转换为生物活性分子,以及致癌作用和药物代谢.综述了细胞色素P450结构与功能的关系,特别是细胞色素P450对底物的选择性以及催化机制,并对其未来的发展方向进行了展望.

The cytochrome P450s （CYPs） are ubiquitous heine-containing mixed function monooxygenases and involved in a number of vital processes including carcinogenesis and drug metabolism as well as the biosynthesis of steroid hormones and fat-soluble vitamin metabolism and the conversion of polyunsaturated fatty acids to biologically active molecules. Recent advances in understanding structurefunction relationships, especially the substrate selections and catalytic mechanisms in cytochrome P450 are summarized. Further research focuses are also discussed.