支气管哮喘发病机制研究进展

Research progress of bronchial asthma pathogenesis

气道重塑是一个复杂的过程,在支气管哮喘发病机制中越来越受到重视。其产生的原因很多,但血小板衍生生长因子-BB的刺激、STIM 1/Orai1介导的Ca2+内流的确切机制还不清楚,阐明这些因素将为发现新的防治或逆转气道结构变化的治疗方法提供帮助。

Airway remodeling is a complex process,the role of airway remodeling in the bronchial asthma pathogenesis is more and more important. While information concerning the factors of remodeling is abundant,the PDGF-BB stimulation, STIM1 and Orail regulate Ca2＋ influx in airway smooth muscle cells are far from being resolved. Elucidation of these factors will lead to novel therapies designed to prevent or reverse these changes.