蔗糖铁联合促红细胞生成素对维持性血液透析病人肾性贫血疗效评价

Evaluation of the Therapeutic Effect of Iron Sucrose Combined with Erythropoietin on Maintenance Hemodialysis Patients with Renal Anemia

目的探讨观察蔗糖铁联合促红细胞生成素对维持性血液透析病人肾性贫血的疗效。方法按照随机数字表法将135例患者随机分为观察组(67例)和对照组(68例),所有患者均给予促红细胞生成素治疗,观察组患者采用蔗糖铁治疗,对照组患者采用琥珀酸亚铁治疗。结果治疗后观察组Hb、Hct、SF、TSAT等指标均与对照组差异有统计学意义(P<0.05);观察组不良反应发生率(1.49%)显著低于对照组(7.35%),P<0.05。结论蔗糖铁联合促红细胞生成素联合治疗维持性血液透析病人肾性贫血的疗效确切,不良反应轻微,值得临床借鉴。

Objective To observe the therapeutic effect of iron sucrose combined with erythropoietin on maintenance hemodialysis patients with renal anemia. Methods According to random number table method, 135 patients were randomly divided into observation group（67 cases） and control group （68 cases）. On the basis of erythropoietin therapy, the patients in the observation group were treated with iron sucrose, and patients in the control group were treated with ferrous succinate. Results After the treatment, there were significant differences between the observation group and the control group in the indexes such as Hb, Hct, SF and TSAT, P〈 0.05. The observation group＇s incidence of adverse reactions（1.49%）was obviously lower than that（7.35%） of the control group, P〈 0.05. Conclusion Iron sucrose combined with erythropoietin have definite therapeutic effect and mild adverse reactions in the treatment of maintenance hemodialysis patients with renal anemia, and which is worthy of clinical reference.