摘要
恶性肿瘤最基本的生物学特征之一是细胞周期调控紊乱导致的细胞恶性转化和肿瘤细胞失控性增殖。了解细胞周期的调控机制能够揭示肿瘤发生发展的本质,阐释癌症的发生机制,从而为肿瘤的早期诊断和临床治疗提供分子标志物及药物靶点。本综述通过分析参与细胞周期运转的重要蛋白分子以及这些分子在细胞癌变和临床肿瘤防治过程中的作用,探讨基于这些分子的药物研发,从而系统地阐述细胞周期紊乱对肿瘤发生发展的生物学影响及其对肿瘤诊断与治疗的理论和实践意义。
Dysregulated cell cycle-mediated cell transformation and uncontrolled cell growth are some of the fundamental biolog- ical features of malignant tumors. Thus, understanding the mechanism(s) involved in the cell cycle will facilitate the discovery of the na- ture of tumor initiation and progression as well as the molecular mechanism of tumor malignancy. Consequently, biomarkers and drug targets for early diagnosis and treatment would be obtained. This study was designed to analyze in detail the key regulators of cell cycle and their importance in carcinogenesis and clinical prevention, diagnosis and treatment, and anti-cancer drug discovery. The biological impact of the dysregulated cell cycle on tumor occurrence and malignancy development is systematically described. The theoretical and practical significance of the cell cycle regulation in tumor diagnosis and therapy are also provided.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2014年第1期1-7,共7页
Chinese Journal of Clinical Oncology
基金
国家973重大基础研究项目(编号:2009CB521801)
国家自然科学基金项目(编号:81230047)资助~~
关键词
细胞周期
肿瘤
转化医学
cell cycle, tumor, translational medicine