携带磁性纳米颗粒载药微囊的制备及肿瘤治疗的应用研究进展

Recent development in preparation and application of drug-loaded magnetic nanoparticle-modified microcapsules

通过磁场操控使携带磁性纳米颗粒的微囊富集在生物体特定部位,可实现微囊对特定组织或器官的靶向输送。负载抗肿瘤药物的磁性微囊既可以磁靶向到肿瘤组织,又有缓释、控释药物的优点,已成为实现肿瘤靶向治疗的新型药物载体。本文综述了脂质体、聚合物电解质微囊、聚合物微球等药物载体携带磁性纳米颗粒的制备方法,及其用于抗肿瘤药物载体的基础研究进展。

Coupled magnetic nanoparticles in the microcapsule structure, such as magnetic microcapsules, can be delivered in specific organism or tissues under magnetic field exposure. Thus, the microcapsules can achieve active targeting functions by manipulat- ing the magnetic field. Based on the magnetic microcapsules, the antitumor drugs can also be loaded to realize magnetic response, which gives microcapsules sustained and controlled release advantages. To date, the drug microcapsules carrying magnetic nanoparti- cles have become promising novel delivery carriers for the treatment of tumor diseases. This paper mainly reviews the method of prepa- ration of the magnetic nanoparticle-coupled microcapsules, including liposomes, polyelectrolyte microcapsules, and polymer micro- spheres. The basic research progress of these microcapsules as anticancer drug carriers for the tumor therapy was also reviewed.