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前列腺凋亡应答蛋白4促凋亡和肿瘤特异性抑制作用的研究进展 被引量：4

Pro-apoptosis and selective anticancer activities of prostate apoptosis response protein 4: research progress and prospects
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摘要 前列腺凋亡应答蛋白4(Par-4)作为促凋亡因子,最先在雄性激素不依赖型前列腺癌细胞(AT-3)中发现。内源性Par-4使癌细胞对凋亡刺激更敏感化,但是外源性Par-4可选择性地直接导致癌细胞凋亡,并通过基因突变实验发现该活性依赖于它的核心结构域SAC。Par-4和SAC可特异性地导致癌细胞凋亡,因此是潜在的癌症靶点治疗药物。本文综述了Par-4的发现、结构、功能及其在细胞内信号通路,最后讨论了Par-4和SAC在癌症临床治疗中的应用前景以及在基础研究和临床应用中存在的问题。 As a pro-apoptotic factor, prostate apoptosis response protein 4 （par-4） was first found in the male hormone-dependent prostate cells （AT-3）. Endogenous Par-4 sensitizes cancer cells to apoptotic stimuli, but exogenous Par-4 selectively induces apoptosis in cancer cells, and these activities depends on the structure of its core domain SAC. Par-4 and SAC can specifically induce apoptosis of cancer cells but not of normal cells, and are therefore potential anti-cancer drugs. In this review we summarize the discovery, structure, and function of par-4, and its intraceUular signaling pathways, then discuss the application prospects of Par-4 and SAC in the clinical treatment of cancer and the problems in its research and clinical applications.
作者 吴增丁 王冠林 张宽仁
机构地区 昆明理工大学生命科学与技术学院分子药理组
出处 《南方医科大学学报》 CAS CSCD 北大核心 2014年第1期128-132,共5页 Journal of Southern Medical University
基金 国家自然科学基金(81360162 81260351)~~
关键词 前列腺凋亡应答蛋白4 SAC 细胞凋亡 肿瘤抑制 prostate apoptosis response protein 4 SAC apoptosis anti-cancer
分类号 R730.5 [医药卫生—肿瘤]
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参考文献37

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共引文献58

同被引文献34

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南方医科大学学报
2014年 第1期

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