磷酸肌酸钠对老年高血压并心力衰竭患者血浆CT-1、NT-proBNP的影响

Effects of Creatine Phosphate Sodium on Plasma Cardiotrophin-1 and N Terminal Probrain Natriuretic in Elderly Hypertensive Patients with Heart Failure

目的探讨磷酸肌酸钠对老年高血压并心力衰竭(心衰)患者血浆心肌营养素-1(CT-1)、N末端B型利钠肽原(NT-proBNP)水平的影响。方法选择年龄≥65岁的高血压并心衰患者76例,分层随机法分为治疗组和对照组各38例,对照组常规抗心衰治疗,治疗组常规抗心衰治疗加用磷酸肌酸钠,2周后评定2组血浆CT-1、NT-proBNP的变化及心衰症状情况。血浆CT-1水平采用双抗体夹心酶联免疫吸附法(ELISA)测定,NT-proBNP水平采用锐普荧光干式定量分析仪检测。结果治疗后2组血浆CT-1、NT-proBNP水平均较治疗前降低(P<0.01),治疗组血浆CT-1、NT-proBNP水平较对照组下降更明显(P<0.05)。治疗组总有效率89.47%,高于对照组的71.05%(P<0.05)。治疗组1周心衰症状改善21例,2周13例,对照组1周9例,2周18例。结论常规治疗加用磷酸肌酸钠可降低老年高血压并心衰患者血浆CT-1和NT-proBNP水平,在更短的时间内改善患者心力衰竭症状。

Objective To investigate the effect of hosphocreatine therapy on the plasma cardiotrophin-l（CT-1） and N terminal probrain natriuretic （NT-proBNP） in elderly hypertensive patients with heart failure. Methods A total of 76 hy- pertensive patients with heart failure, aged 65 or over, were randomly divided into treatment group and control group （n=38 for each group）. The control group received routine anti-heart failure treatment. The treatment group received conventional therapy plus creatine phosphate sodium for 2 weeks. The plasma levels of CT- 1 and NT-proBNP were determined in two groups. The plasma CT- 1 level was measured by a double antibody sandwich enzyme-linked immunosorbent assay （ELISA）. The plasma level of NT-proBNP was tested by Rui Pu fluorescent dry quantitative analyzer. Results The plasma levels of CT-1 and NT-proBNP were significantly lower after treatment in two groups （~ 〈 0.01）. The plasma levels of CT-1 and NT- proBNP were significantly decreased in treatment group than those in control group （P 〈 0.05）. The total effective rate was J 89.47% in treatment group, which was significantly higher than that of control group （71.05%, P 〈 0.05）. Symptoms of heart failure improved in one week （21 cases in treatment group/9 cases in control group） and in two weeks （13 cases in treatment group/18 cases in control group）. Conclusion The conventional therapy plus creatine phosphate sodium can decrease the plasma CT- 1 and NT-proBNP levels in elderly hypertensive patients with heart failure, which improves symptoms of heart failure in a shorter period of time.