慢性胰腺炎患者血清对氧磷酶1活性变化

Changes of serum paraoxonase 1 activity in patients with chronic pancreatitis

目的探讨血清对氧磷酶1活性与慢性胰腺炎发病的关系。方法 152例慢性胰腺炎患者(观察组)和128例体检健康者(对照组),采用分光光度法检测血清对氧磷酶1活性,并进行2组间比较。结果观察组血清对氧磷酶1活性((412.56±135.86)u/mL)明显低于对照组((582.74±176.37)u/mL)(P<0.01);多因素logistic回归分析结果显示,血清对氧磷酶1活性降低是慢性胰腺炎发病的独立危险因子。结论血清对氧磷酶1可作为预测慢性胰腺炎发病的一项血清学标志物。

Objective To explore the relationship of serum paraoxonase 1 activity with the pancreatitis. Methods The serum paraoxonase 1 activity was detected in 152 patients w pat ith hogenesis of chronic chronic pancreatitis （observation group） and 128 healthy controls （control group） by spectrophotometry and compared between two groups Results The serum paraoxonase 1 activity was （（412.56 ± 135.86） u/mL） in observation group, significantly lower than that in control group （（582. 74± 176. 37） u/mL） （P〈0.01）. Multivariable logistic regression analysis revealed that serum paraoxonase 1 activity was an independent factor for chronic pancreatitis. Conclusions The reduced serum paraoxonase 1 activity could serve as a predictive serum marker for the development of chronic panereatitis.