南京地区呼吸道感染患儿的肺炎支原体感染流行病学特征

Epidemiological characteristics of mycoplasma pneumoniae infection in children with respiratory tract infection in Nanjing area

目的分析2010年南京地区呼吸道感染患儿的肺炎支原体（MP）感染流行病学特征。方法呼吸道感染患儿8685例，按年龄分为A组（1d--，878例）、B组（29d--，3307例）、C组（1岁～，2069例）、D组（3岁～，1558例），E组（6岁一14岁11个月，873例）。采用FQ-PCR法对患儿呼吸道分泌物标本进行MP-DNA检测。MP-DNA阳性患儿中，上呼吸道感染23例（F组），下呼吸道感染2731例（G组），比较两组MP-DNA拷贝数log值。结果女性患儿MP-DNA阳性率高于男性患儿（38．15％VS．31．33％）（PG0．01），C、D组女性患儿MP-DNA阳性率均高于男性患儿（PG0．01或PG0．05），不同年龄组MPDNA阳性率比较有统计学差异（P〈0．01）。夏、秋季患儿MP-DNA阳性率高于春、冬季患儿（43．63％、47．01％vs．27．64％、20．68％）（PGO．05）。A、B、C和D组内患儿四季MP-DNA阳性率比较有统计学差异（PG0．01）。G组MP-DNA拷贝数log值高于F组（5．74±1．42VS．4．71±1．25）（P〈0．01）。结论南京地区呼吸道感染患儿MP感染存在性别差异，学龄前期和学龄期为儿童MP感染高发年龄，夏、秋季为本地区MP感染高发季节。

Objective To investigate the epidemiological characteristics of mycoplasma pneumoniae（MP） infection in children with respiratory tract infection（RTI） in Nanjing area in ~010. Methods A total of 8685 children with RTI was divided into five groups of A （1 d-,878 cases） ,B（29 d-, 3307 cases）,C（one year-, 2069 cases）,D（3 years-, 1558 cases） and E（aged from 6 years to 14 years and 11 months,873 cases）. MP-DNA in sample of respiratory secretions was detected by RQPCR. Some of children with MP-DNA positive were divided into groups of F（with upper RTI,23 cases） and G（with lower RTI, 2731 cases）, and the log value of MP-DNA copy number was compared between two groups. Results The positive rate of MP-DNA in female children was higher than that in male children（38.15% vs. 31.33%） （P〈0. 01）. In groups of C and D, the positive rate of MP-DNA in female children was higher than that in male children（P〈0. 01 or P〈0. 05）. There were significant differences in the positive rates of MP-DNA among five groups（P〈0. 01）. The positive rates of MP-DNA occurred in the summer and autumn were higher than those in the spring and winter （43.63% and 47. 01% vs. 27.64% and 20. 68%） （P〈0. 05）. There were significant differences in the positive rates of MP-DNA in all seasons among groups of A, B, C and D（P〈0. 01）. The log value of MP-DNA copy number in group G was higher than that in group F（5.74± 1.42 vs. 4.71 ± 1.25） （P〈0. 01）. Conclusion There is gender difference in MP infection in children with RTI. Children at preschool and school ages and in the summer and autumn seasons run a high risk for MP infection.