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IKKε在卵巢癌中的表达及临床意义 被引量：3

Expression and clinical significance of IKKε in ovarian cancer
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摘要 目的探讨I-κB激酶ε(IKKε)在卵巢癌组织中的表达及与卵巢癌转移的关系。方法采用实时定量PCR(qRT-PCR)和Western blot法分别检测53例不同临床分期的卵巢癌组织和10例正常卵巢组织中IKKεmRNA和蛋白表达,并分析IKKε表达与卵巢癌转移的相关性。结果Ⅱ、Ⅲ、Ⅳ期卵巢癌组织中IKKεmRNA和蛋白表达高于正常卵巢组织和Ⅰ期卵巢癌组织(P<0.05),且IKKε表达随着卵巢癌临床分期升高而增加(P<0.05),但与卵巢癌的病理类型、组织学分型及年龄无明显相关性(P>0.05)。结论 IKKε表达与卵巢癌的临床分期密切相关,可望成为临床治疗卵巢癌的一个新靶点。 Objective To investigate I-kB kinase ε（IKKε） expression in ovarian Cancer tissues and its correlation with tumor metastasis. Methods The mRNA and protein expressions of IKKε were detected by quantitative RT-PCR and Western blot in 53 cases of ovarian cancer in different clinical stages and 10 cases of normal ovarian tissues, respectively. Then the correlation between the expressions and ovarian cancer metastasis was analyzed. Results The mRNA and protein expressions of IKKε in ovarian cancer in stage Ⅲ-Ⅳ were significantly higher than those in ovarian cancer in stage I and normal ovarian tissues （P〈0. 05）. IKKε expression was up-regulated with the increase of clinical stages of ovarian cancer （P〈0. 05 ）, but had no significant correlation with pathological pattern, histological classification and age （P〈0. 05）. Conclusion IKKε expression is closely correlated with clinical stages of ovarian cancer, which may be taken as a new target for the treatment of ovarian cancer in the future.
作者 成开花
机构地区 东南大学医院妇产科
出处 《江苏医药》 CAS 北大核心 2014年第1期63-66,共4页 Jiangsu Medical Journal
关键词 I-kB激酶ε 卵巢癌 I-kB kinase εOvarian cancer
分类号 R737 [医药卫生—肿瘤]
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参考文献12

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共引文献3

同被引文献32

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引证文献3

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江苏医药
2014年 第1期

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