IL-6和B型脑钠肽检测在急性ST段抬高心肌梗死中的临床价值

Clinical value of interleukin-6 and B-type natriuretic peptide in patients with acute ST-segment elevation myocardial infarction

目的探讨检测IL-6和B型脑钠肽(BNP)在急性ST段抬高心肌梗死(STEMI)中的临床价值。方法 ELISA法和双抗体夹心免疫荧光法分别检测急性STEMI患者(A组,102例)和正常对照(B组,30例)静脉血IL-6和BNP水平,并行冠脉造影结果Gensini积分评价,随访3个月主要不良心血管事件发生情况。结果 A组IL-6和BNP水平均显著高于B组[(13.43±7.64)pg/ml vs.(8.39±3.37)pg/ml和(278.16±575.03)pg/ml vs.(39.91±55.99)pg/ml](P<0.01)。IL-6与Gensini积分呈正相关(r=0.26,P<0.05);BNP与Gensini积分呈正相关(r=0.23,P<0.05)。发生主要不良心血管事件患者的IL-6和BNP水平均显著高于未发生者[(20.20±9.66)pg/ml vs.(11.56±5.79)pg/ml和(735.35±1047.80)pg/ml vs.(152.43±238.03)pg/ml](P<0.01)。结论 IL-6和BNP水平与冠状动脉病变的严重程度及近期预后相关。

Objective To explore the clinical value of interleukin-6（IL-6）and B-type natriuretic peptide（BNP） detection in patients with acute ST-segment elevation myocardial infarction（STEMI）. Methods Serum levels of IL-6 and BNP were detected by ELISA and ELMA respectively in the patients with acute STEMI（group A, 120 cases） and healthy people（group B, 30 cases）. The result of coronary angiogram was evaluated by Gensini score. Major adverse cardiovascular events （MACE） were followed up within three months. Results Serum levels of IL-6 and BNP were higher in group A than those in group B[（13. 43±7. 64） pg/ml vs. （8. 39±3.37） pg/ml and（278. 16±575.03） pg/ml vs. （39.91± 55.99） pg/ml] （P〈0. 01）. Serum levels of IL-6 and BNP were positively correlated with Gensini score（r=0. 26, r=0. 23, P〈0. 05）, which in patients with MACE were higher than those without MACE[（20. 20±9.66） pg/ml vs. （11.56±5.79） pg/ml and （735.35±1047.80） pg/ml vs. （152. 43 ± 238. 03） pg/ml] （P〈0. 01）. Conclusion Serum levels of IL-6 and BNP are correlated with the severity of coronary artery lesions and short-term prognosis.