同型半胱氨酸、高敏C反应蛋白及D-二聚体在急性脑梗死患者中的变化及意义

The changes of serum homocysteine,high sensitivity C reactive protein and D dimer levels in acute cerebral infarction patients and its clinical significance

目的观察血清同型半胱氨酸(Hey)、高敏C反应蛋白(hs-CRP)及D-二聚体(D-D)水平与急性脑梗死的关系。方法选择90例急性脑梗死患者作为脑梗死组,根据梗死灶大小又分为小面积亚组(n=30),中面积业组(n=24)和大面积亚组(n=36),再根据临床神经功能缺损严重程度分为轻度亚组(n=33)、中度亚组(n=19)和重度亚组(n=38);另选同期健康体检者90例作为健康对照组。检测2组血清同型Hcy、hs-CPR及D-D水平,并作对比分析。结果脑梗死组患者血清中Hcy、hs-CRP、D-D的含量均明显高于健康对照组(P<0.05);大面积亚组患者血清Hcy、hs-CRP、D-D的含量>中面积亚组>小面积亚组(P<0.05);重度亚组患者血清中的Hcy、hs-CRP、D-D的含量>中度亚组>轻度亚组(P<0.05)。结论 Hcy、hs-CRP和D-D与急性脑梗死的发生发展有密切关系,检测其水平对于判断疾病的严重程度,指导临床治疗具有重要的意义。

Objective To investigate the changes of serum homocysteine（Hey）,high sensitivity C reactive protein（hs-CRP）and D-dimer（D-D）levels in acute cerebral infarction patients and its significance.Methods 90 patients with acute cerebral infarction as cerebral infarction group,according to the infarct size,patients were divided into small-area subgroup（n=30）,middle-area subgroup（n=24）and large-area subgroup（n=36）,according to the severity,further divided into mild subgroup（n=33）,moderate subgroup（n=19）and severe subgroup（n=38）.Selected 90 cases over the same period as the healthy control group,detected serum Hcy,hs-CPR and D-D levels and to make comparative analysis.Results Serum of patients with cerebral infarction Hcy,hs-CRP,D-D levels were significantly higher than the healthy control group（P0.05）;Hey,hs-CRP,D-D levels in large-area subgroupmiddle-area subgroupsmall-area subgroup（P0.05）;serum Hey,hs-CRP,D-D levels in severe subgroupmoderate subgroupmild subgroup（P0.05）.Conclusion Hey,hs-CRP and D-D and is closely related to the occurrence and development of acute cerebral infarction,the datecLion level for judging its severity,clinical treatment has important significance.