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晚期糖基化终产物受体在肺部疾病中的表达及作用 被引量：2

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摘要 晚期糖基化终产物受体（RAGE）是一种细胞跨膜型蛋白受体,可以与多种配体相互作用形成配体—RAGE轴,激活细胞内多条信号通路,从而通过增强氧化应激反应、改变细胞功能等引起疾病的发生。早期发现于代谢性疾病如糖尿病中,可以与糖代谢终极产物（AGEs）相结合影响疾病的发生发展。RAGE与糖尿病、动脉粥样硬化等血管性疾病、中枢及外周神经性疾病、免疫性疾病等证实有着紧密关系,并且是体内重要信号通路的枢纽。
作者 逯佳(述) 崔晓光(审)
机构地区 哈尔滨医科大学第二附属医院麻醉科/黑龙江省麻醉与危重病学重点实验室/黑龙江省普通高等学校麻醉基础理论与应用研究重点实验室
出处 《疑难病杂志》 CAS 2014年第1期105-107,共3页 Chinese Journal of Difficult and Complicated Cases
关键词 晚期糖基化终产物受体 COPD 支气管哮喘 肺缺血再灌注损伤
分类号 R36 [医药卫生—病理学]
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参考文献35

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二级参考文献44

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共引文献29

同被引文献39

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疑难病杂志
2014年 第1期

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