临床干预后耐甲氧西林金黄色葡萄球菌感染变化研究

Study on the change of Methicillin-Resistant Staphylococcus Aureus infections after clinical intervention

目的探讨耐甲氧西林金黄色葡萄球菌（MRSA）临床干预后的临床感染特点和耐药性变化。方法采用回顾性调查的方法来收集该院2009～2011年金黄色葡萄球菌感染的住院患者病历资料，分析MRSA检出率、感染部位和科室分布特点及其对抗菌药物的耐药性；比较干预措施前后MRSA检出率并评价其干预措施的效果。结果2009～2011年住院患者微生物检验标本检出1150株金黄色葡萄球菌，其中MRSA704株，检出率为61．1％。2009年检出MRSA178株，检出率为66．4％；2010年检出MRSA264株，检出率为63．2％；2011年检出MRSA262株，检出率为56．5％。MRSA感染部位以呼吸系统和皮肤软组织常见，好发于脑外科、重症监护室、骨科、烧伤科和皮肤科。结论临床干预后，MRSA的感染率有所下降，证明针对MRSA感染的干预措施有效。

Objective To investigate the change of features to clinical infection and resistance to antibiotics of methicillin-resist- ant Staphylococcus aureus （MRSA） infections after intervention. Methods The retrospective investigation was used to collect the medical records of hospitalized patients in MRSA infection from 2009 to 2011 and analysis of MRSA detection rate,infection site, the feature of department distribution and its to antibiotics drug resistance;Compared the difference between before and after inter- vention of MRSA detection,and evaluated the effects of interventions. Results In hospitalized patients, 1150 strains of S. aureus were isolated from 2009 to 20il,704 strains among those were MRSA,and the detection rate accounted for 61.1%. In 2009,178 strains of MRSA were isolated,and the detection rate was 66.4%, in 2010,264 strains of MRSA were isolated, the detection rate was 63.2 %, In 2011,262 strains of MRSA were isolated. The detection rate was 56.5 %. The sites of MRSA infection on respirato ry system,skin and soft tissue in hospitalized patients were common. MRSA infection often occurred in the department of cerebral surgery,ICU room,department of orthopedics,department of burns and department of dermatology. Conclusion With the clinical intervention,the MRSA infection rate can be reduced. The intervention against MRSA infection has been proved effectively.