转化生长因子-β1基因T869C多态性与腔隙性脑梗死的关系

Correlation of TGF-1 T869C gene polymorphism with lacunar infarction

目的:探讨转化生长因子-β1(TGF-β1)T869C基因多态性与腔隙性脑梗死(lacunar infarction,LI)的关系。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测143例LI患者(LI组)及138例正常人(对照组)TGF-β1基因T869C的多态性。结果:LI组CC基因型频率(36.3%,52/143)显著高于对照组(21.0%,29/138,OR=2.18,P=0.002),LI组C等位基因频率显著高于对照组(58.1%vs 46.7%,OR=1.57,P=0.004)。结论:TGF-β1基因T869C位点的基因多态性与LI有关,C等位基因是LI的危险因素。

Objective To investigate the correlation of transforming growth factor （TGF）-β1 T869C gene polymorphism with lacunar infarction （LI）. Methods The genotyes of TCF-β1 T869C gene were determined by PCR-based assay in 143 patients with LI and 138 healthy controls. Results The frequency of T869C C allele was significantly higher in the LI group than that in the healthy controls （P = 0.002）. The distribution of T869C polymorphism demonstrated that LI patients had higher TGF-β1 T869C CC frequency comparing with that in the healthy controls （P = 0.004）. Conclusion The TGF-β1 T869C gene polymorphism is associated with LI, TGF-β1 T869C C allele may be an independent risk factor for LI.