藏红花对酒精及酒精加四氯化碳所致大鼠肝损伤的防治作用

Prevention and Treatment of Saffron on Experimental Alcoholic and CCI_4 Liver Injury in Wistar Rats

探索藏红花对酒精及酒精四氯化碳所致大鼠肝损伤的防治作用。方法:取Wistar雄性大鼠设5组,分别灌胃生理盐水(A)、白酒(B)、白酒加藏红花(C)、白酒加CCl_4(D)、在D组基础上加用藏红花(E);对5组大鼠血清ALT和肝脏组织学病变进行比较。结果:藏红花能降低白酒和四氯化碳引起的ALT升高(P<0.05);B、C组及D、E组互比肝脏组织学改变有明显差异(P<0.05)。结论:藏红花对酒精及酒精四氯化碳所致肝损伤有一定的防治作用。

To explore saffron in the treatment of alcohol and CCl4 induced liver injury in the rat. Methods:Five groups (ten rats/group) of male wistar rats were studied. Rats in group A were fed 0. 9% NaCl continuously for up to 8 weeks via intragastric feeding; Rats in group B and C were fed ethanol (9-11g/kg/d) continuously for up to 8 weeks via intragastric feeding. At the same time rats in C group were added saffron: Rats in group D and E were fed ethanol for 4 weeks, then being exposed to CCl4 (0. 0125ml/100g, 3 times/week) for 4 weeks,Rats in group E were given saffron too. ALT and liver specimens was measured and evaluted. Results; Serum level of ALT decreased significantly (P< 0. 05) in saffron rats as compared with alcoholic and CCl4 rats.Liglt microscopic examination showed that Saffron groups have abvious pathological changes. Conclusion: Saffron may be therapeutically useful and prevention in the alcohol and CCl4 hepatic injury in rats.