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213例宫颈上皮内瘤变Ⅰ期临床疗效观察分析 被引量:5

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摘要 目的:探讨对比单纯使用干扰素或单纯使用LEEP,干扰素联合LEEP及对照组对CINⅠ的疗效观察。方法:选自CINI患者221例。根据自愿选择原则分为4组,第1治疗组使用干扰素治疗55例,第2治疗组单纯使用LEEP治疗53例,第3治疗组使用干扰素+LEEP治疗56例,第4组为对照组57例。结果:使用辛复宁组治疗1组及3组有效率为71%及85%,与未使用辛复宁组治疗2组及对照组对比,p<0.005,有统计学意义。对治疗CINⅠ的疗效中,治疗1组与对照组对比,p<0.005,有统计学意义。治疗2组与对照组对比,p<0.005,有统计学意义。治疗3组与对照组对比,p<0.005,有统计学意义。治疗3组与治疗1组对比,p<0.005,有统计学意义。治疗3组与治疗2组对比,p<0.005,有统计学意义。治疗1组与治疗2组对比,p>0.1,无统计学意义。结论:干扰素能有效地治疗宫颈持续性HPV感染,局部用药简单、方便、副反应少。对于宫颈上皮内瘤样病变用重组人干扰素α-2b联合LEEP治疗CINⅠ的疗效最佳,优于单纯的LEEP或单纯的辛复宁治疗,而用辛复宁及LEEP,或用辛复宁加LEEP均比对照组疗效好。辛复宁栓剂联合LEEP治疗CIN是一种安全、高效的治疗的方法,值得临床推广应用。
作者 袁涛 李晓
出处 《中国伤残医学》 2014年第2期107-108,共2页 Chinese Journal of Trauma and Disability Medicine
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