南极来源真菌GW3-13产chetracin B发酵优化研究

Fermentation optimization for the production of chetracin B from the Antarctic Fungus Oidiodendron truncatum GW3-13

目的提高菌株Oidiodendron truncatum GW3-13产chetracin B的产量。方法采用单因素及均匀设计方法,对菌株GW3-13产chetracin B的培养条件及培养基组成进行了优化。结果得到了菌株GW3-13产chetracin B最适培养基组成及最适发酵条件。结论在优化条件下,菌株GW3-13产chetracin B可达到(30.1±1.5)mg·L-1,比优化前提高了6.7倍。

Objective To increase the yield of chetracin B produced by oidiodendron truncantum GW3-13. Methods The fermentation conditions and medium of GW3-13 were studied by using Single factor experiment and uniform design. Results The optimized fermentation medium and culture conditions for GW3- 13 producing chetracin B were obtained. Conclusion The chetracin B production reached 30. 1 ± 1.5 mg · L^-1 under the optimized conditions, which was 6.7 times higher than the original conditions.