女性血脂异常与心血管疾病

Abnormal blood lipid and cardiovascular disease in females.

女性作为一个特殊群体,其首位致死原因为心血管疾病。女性冠心病发生率增加不仅与雌激素有关,而且与血脂异常关系重大,后者多发生于绝经后。与男性相比,女性总胆固醇在绝经后开始升高,同时高密度脂蛋白胆固醇出现下降,前者与女性冠心病明显相关,低水平的高密度脂蛋白胆固醇更是女性冠心病的独立危险因素。目前,指南推荐在高危人群中应用降脂药物预防冠心病,同时女性应尤其注意用药的安全性。

Summary ： Cardiovascular disease has become the number 1 killer for women, unlike for men. The increase of coronary heart disease （CHD） could be explained not only by estrogen deprivation but also by an abnormal blood lipid, which is likely to occur in the postmenopause period. Compared with males, the total cholesterol levels increase while high density lipopro teincholesterol （HDLC） levels decrease in females after menopause. The level of total cholerterol is significantly associat ed with CHD in females,and moreover,the low level of HDLC is an independent risk factor of female CHD. Current guide line recommends that lipidlowering drugs should be used to prevent CHD in highrisk population; meanwhile, females should oar special attention to the safety of medication.