C-反应蛋白在HIV／AIDS的表达及其相关性研究

Expression of C-reactive protein in HIV/AIDS patients and relevant studies

目的探讨在抗病毒治疗前血清C-反应蛋白(CRP)在人类免疫缺陷病毒感染者/获得性免疫缺陷综合征患者(HIV/AIDS)中的表达及其与WHO临床分期的关系,为研究HIV疾病进展和预后提供理论依据。方法分别测定173例HIV/AIDS及24名健康对照组血清CRP水平,对WHO临床各期及健康对照组的CRP水平进行比较,分析CRP水平与WHO临床分期的相关性。结果 WHO临床I、Ⅱ、Ⅲ、Ⅳ期、健康对照组CRP水平分别为0.05、0.14、3.85、6.10、0mg/L,组间差异有统计学意义(P<0.05);WHO临床Ⅱ、Ⅲ、Ⅳ期CRP水平均分别高于健康对照组(P<0.05),WHO临床Ⅲ、ⅣCRP水平分别高于Ⅱ、Ⅰ期(P<0.05),WHO临床Ⅰ期CRP水平和Ⅱ期差异无统计学意义,WHO临床Ⅲ期CRP水平和Ⅳ期差异无统计学意义;CRP的表达与性别、年龄、CD4细胞、WHO临床分期、体质量指数、血清白蛋白、血红蛋白均相关(P<0.05);调整年龄、性别后,CRP同CD4细胞、体质量指数、血清白蛋白、血红蛋白呈负相关(P<0.05),同WHO临床分期呈正相关(P<0.05)。结论 CRP在HIV/AIDS中呈高表达,与疾病进展呈正相关。

OBJECTIVE To explore the expression of serum C-reactive protein （CRP） in the patients infected with human immunodeficiency virus （HIV） or the patients with acquired immunodeficiency syndrome （AIDS） before the antiviral therapy and study its correlation with the clinical staging of WHO so as to provide theoretical basis for the study of progression and outcome of the HIV infections. METHODS The levels of serum CRP were respectively determined for 173 cases of HIV/AIDS and 24 healthy people, then the clinical stages of WHO and the levels of serum CRP were observed and compared, and the correlation between the level of serum CRP and the clinical stag- ing was analyzed. RESULTS The level of serum CRP was 0.05 mg/L in the WHO stage Ⅰ, 0.14 mg/L in the WHO stage Ⅱ , 3.85 mg/L in the WHO stage Ⅲ , 6.10 mg/L in the WHO stage Ⅳ, 0 mg/L in the control group, the difference was statistically significant（P〈0.05） ; the levels of serum CRP were respectively higher in the WHO stage Ⅱ , Ⅲ, or Ⅳ than in the control group （all P〈0.05） ; the level of serum CRP in the WHO stage UI or Ⅳ was higher than that in the WHO stage Ⅱ or Ⅰ （all P〈0.05） ; the difference in the level of serum CRP between the WHO stage Ⅰ and the WHO stage Ⅱ was not statistically significant; the difference in the level of serum CRP between the WHO stage Ⅲ and the WHO stage IV was not statistically significant. The expression of CRP was re- lated to the gender, age, CD4 , WHO clinical staging, body mass index, serum albumin, and hemoglobin （all P〈 0.05） i after the age and gender were adjusted, the expression of CRP was negatively correlated with the CD4, body mass index, serum albumin, and hemoglobin （all P〈0.05） hut was positively correlated with the WHO clinical staging （P〈0.05）. CONCLUSION The HIV/AIDS patients demonstrate a high expression of CRP, which is positively correlated with the progression of disease.