非酒精性脂肪肝患者血清白介素-6的检测及意义

Significance of serum levels of interleukin-6 in patients with nonalcoholic fatty liver disease

目的探讨白介素-6(IL-6)在非酒精性脂肪肝(NAFLD)发生与发展中的作用。方法选择NAFLD患者132例,正常对照132例。测量身高、体质量、腰围、血压,检测肝功能、血糖、血脂、尿酸和白细胞计数等指标。采用酶联免疫法检测病例与对照者血清IL-6水平,分析NAFLD的影响因素。结果 NAFLD组体质量指数、腰围、血生化、血压水平均高于对照组(P<0.05)。NAFLD患者血清IL-6和白细胞计数水平均明显高于对照组(P<0.05)。Spearman相关分析结果显示,NAFLD与血清IL-6和WBC水平呈正相关(P<0.05)。单因素分析显示,IL-6、WBC、BMI、WC、SBP、DBP、ALT、AST、UA、TG差异均有统计学意义(均为P<0.05),而GLU、CHOL差异无统计学意义(P>0.05)。多因素Logistic回归分析显示BMI、血清IL-6、收缩压是NAFLD的危险因素(P<0.05)。结论非酒精性脂肪肝患者血清IL-6水平明显升高,提示IL-6可能在非酒精性脂肪肝的发生发展中起重要作用。

[ Objective] To detect and evaluate the significance of serum interleukin-6 （IL-6） levels in patients with nonalcoholic fatty liver disease （NAFLD）. [Methods] A total of 264 individuals were evenly di vided into NAFLD group and control group. Body mass index （BMI）, waist circumference （WC）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were measured. The levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, fasting serum glucose （GLU）, triglyceride （TG） and total cholesterol （TC）, uric acid （UA） and white blood cell count （WBC） were detected. Serum IL-6 levels were determined by enzyme-linked immunosorbent assay （ELISA）. The risk factors of NAFLD were analyzed. [Results] The levels of IL-6 were significantly higher in NAFLD patients compared with control group （P〈0.05）. Serum IL-6 lev els and white blood cell count in the NAFLD group were evidently higher than those in control group （P 〈 0.05）. Spearman Correlation analysis showed that serum IL-6 levels and white blood cell count were positively correlated with NAFLD （P 〈0.05）. One-way analysis of variance found that the two groups were significantly different in IL-6, WBC, BMI, WC, SBP, DBP, ALT, AST, UA, TG （P〈0.05）, but GLU, CHOL were not sig nificantly different （P〉0.05）. Multivariate logistic regress analysis show that BMI, serum IL-6 and SBP werethe risk factors of NAFLD （P〈0.05）. [Conclusion] The levels of IL-6 were significantly increased in NAFLD patients, suggesting that IL-6 might play an important role in the pathogenesis of non-alcoholic fatty liver dis ease.