肝硬化患者联合检测血清视黄醇结合蛋白、前白蛋白、白蛋白、胆碱酯酶的临床意义

Clinical significance of combination detection of serum retinol-binding protein, pre-albumin,albumin and cholinesterase for patients with liver cirrhosis

目的:探讨肝硬化患者联合检测血清视黄醇结合蛋白(RBP)、前白蛋白(PA)、白蛋白(ALB)、胆碱酯酶(CHE)的临床意义。方法:分别采用免疫透射比浊法、终点法、溴甲酚绿法、丁酰硫代胆碱/铁氰化钾法检测81例不同程度(按Child-Pugh分级)肝硬化患者(肝硬化组)和35名正常人(对照组)的RBP、PA、ALB、CHE水平。结果:肝硬化组血清RBP、PA、ALB和CHE水平均明显低于对照组(P<0.01)。肝硬化程度由轻到重患者血清RBP、PA、ALB和CHE均依次降低(P<0.01)。结论:联合检测血清RBP、PA、ALB和CHE能更好地反映肝功能损害的严重程度,肝硬化患者病情变化、疗效评价和预后判断具有良好的参考价值。

Objective： To study the clinical value of detecting serum retinol-binding protein （RBP）, pre-albumin （PA）, albumin （ALB） and cholinesterase （CHE） for patients with liver cirrhosis. Methods： Immunotransmission turbidity, end-point method, Bromocreosol creosol green method and Butyrylthiocholine/Potassium ferricyanide method were used to detect the serum RBP, PA, ALB and CItE levels in 81 cases of liver cirrhosis of various degrees（ according to the Child-pugh grading） ;and 35 healthy persons acted as control. Results：Compared with the control group, the levels of serum RBP, PA, ALB and CHE in the liver cirrhosis group were decreased significantly （P 〈 0. O1 ）. In patients with liver cirrhosis, the levels of serum RBP, PA, ALB and CHE were decreased according to the Child-pugh grading with marked differences （P 〈 0.01 ）. Conclusions：Combination detection of serum RBP, PA, ALB and CHE could effectively monitor the degree of liver damage, which has great reference value in evaluating the pathogenetic condition, curative effect and prognosis of patients with liver cirrhosis.