水貂犬瘟热临床病理组织学观察

Study of clinical histopathology on mink infected with canine distemper virus

本研究对实验室确诊为犬瘟热的患貂的主要脏器进行了病理组织学观察。结果显示,病貂的心肌细胞间隙明显增宽,有炎性细胞浸润;肝脏出血、淤血,炎性细胞浸润及肝细胞肿胀、坏死;脾脏出血,脾小梁增生;肺脏出血,大量炎性细胞浸润,肺泡壁增厚;肾脏炎性细胞浸润,部分肾小管上皮细胞肿胀、坏死;脑组织出现噬神经元和卫星现象,炎性细胞浸润;小肠绒毛断裂,炎性细胞浸润等。结果表明,犬瘟热患貂出现了广泛性的组织损伤,同时伴随着机体各器官明显的炎症反应。

The tissues of the sick mink diagnosed as infected with canine distemper virus were dissected, fixed immediately for making paraffin section and histopathologieal changes of these tissues were observed by light microscope. The result showed that in- tercellular spaces between cardiac myocytes were widened ; and there was hemorrhage and congestion in the liver and necrosis in the liver cell; hemorrhage in spleen and hyperplasia in trabecula; hemorrhage and much inflammatory cell infiltration in the lung, and the alveolar wall became thicker; there was necrosis in renal tubular epithelial cells and much inflammatory cell infihrateion in kid- ney; nearonal autophagy and satellitosis in the brain; intestinal villi disruption and much inflammatory cell infiltration. The result suggested that systemic lesion and inflammatory reaction were the main characteristics of minks infected with canine distemper virus.