思美泰联合中药茵陈利胆方治疗妊娠期肝内胆汁淤积症

Transmetil Combined with Traditional Chinese Medicine Yinchen Cholagogue Decoction in the Treatment of Intrahepatic Cholestasis of Pregnancy

目的评估思美泰(腺苷蛋氨酸针)结合中药茵陈利胆方治疗妊娠期肝内胆汁淤积症(intrahepatic cholestasisof pregnancy,ICP)的效果。方法回顾性收集69例在我院就诊的ICP病人,治疗组35例采用思美泰联合院内自拟"茵陈利胆方"治疗,对照组34例采用单纯思美泰治疗,比较两组治疗前后患者症状缓解情况、血胆汁酸(TBA)、谷丙转氨酶(ALT)及谷草转氨酶(AST)水平的变化并观察妊娠结局,对结果进行统计分析。结果治疗后2组TBA、ALT、AST均较治疗前下降(P<0.05),治疗组治疗后TBA、ALT、AST较对照组治疗后下降幅度更明显(P<0.05),治疗组胎儿窘迫、羊水污染、新生儿窒息、剖宫产率较对照组低(P<0.05)。结论思美泰联合中药茵陈利胆方治疗ICP比单纯思美泰治疗效果显著。

Objective To evaluate the effect of Transmetil （S-adenosylmethionine needle）for treatment of intrahepatic cholestasis of pregnancy （ICP）combined with Chinese traditional medicine Yinchen cholagogue Decoction. Methods We retrospectively collected 69 ICP patientsin in our hospital,35 cases in the treatment group,treated by transmetil combined with traditional Chinese medicine Yinchen cholagogueDecoction,the control group of 34 cases treated by transmetil without Chinese traditional medicine,compared two groups before and after treatment in patients with symptoms,serum bile acid （TBA）,alanine aminotransferase （ALT）and aspartate aminotransferase （AST）levels and observe the pregnancy outcomes,carry on the statistical analysis of the results. Results After treatment,2 groups of TBA,ALT,AST were decreased than that before treatment （P〈0. 05）. After treatment,TBA,ALT,AST decreased more obviously （P〈0. 05）than the control group after treatment,the fetal distress, amniotic fluid contamination,neonatal asphyxia,the rate of cesarean section in the treatment group was lower than that in control group （P〈0. 05）. Conclusion Transmetil combined with traditional Chinese medicine Yinchen cholagogue Decoction in the treatment of ICP has a more obvious effect than pure Transmetil.