滋肾活血方对糖尿病肾病Ⅲ期气阴两虚兼血瘀证患者血液流变学的临床观察

Zishenhuoxuefang Invigorate the Party for Diabetic Nephropathy Stage Ⅲ Qi and Yin Deficiency and Blood Stasis Patients Blood Rheology of Clinical Observation

目的探讨滋肾活血方对156例糖尿病肾病Ⅲ期气阴两虚兼血瘀证患者血液流变学的临床观察。方法将2010年3月-2013年4月柳州市中医院156例糖尿病肾病Ⅲ期患者随机分为治疗组和对照组各78例。两组均采用饮食控制和糖尿病常规治疗。治疗组采用滋肾活血方治疗,对照组采用贝那普利片治疗,疗程12周。结果治疗组血液流变学各项指标、尿蛋白排泄率、血糖及中医症状较治疗前显著下降(P<0.05或P<0.01);与对照组比较血液流变学各项指标、尿白蛋白排泄率(UAER)、血糖、血脂及中医症状改善明显优于对照组(P<0.01或P<0.05)。结论滋肾活血方能改善糖尿病肾病Ⅲ期患者的血液流变学、血脂和微循环,减少尿白蛋白的排出,减轻肾损害,改善肾功能。

Objective Explore Zishenhuoxuefang invigorate the circulation of the 156 cases of diabetic nephropathy stage III qi and Yin deficiency and blood stasis of blood rheology in patients with clinical observation. Methods The traditional Chinese Medicine Hospital of Liuzhou city in 2010 March to 2013 year in April 156 cases of diabetic nephropathy stage III patients were randomly divided into treatment group and control group 78 cases. Both groups were given conventional treatment diet and diabetes. Traditional Chinese medicine treatment group were treated with Zishenhuoxuefang treatment,control group with benazepril tablet treatment,treatment for 12 weeks. Results Treatment group indices of blood,urine protein excretion rate,blood glucose and clinical symptoms decreased significantly compared with before treatment （P〈0.05 or P〈0.01）;compared with the control group the indices of blood,urine albumin excretion rate （UAER）,blood glucose,blood lipids and clinical symptoms improved significantly better than the control group （P〈0.01 or P〈0.05）. Conclusion Zishenhuoxuefang can improve the blood rheology in patients with stage III of diabetic nephropathy,blood lipid and microcirculation,decrease the excretion of urinary albumin,reduce renal damage,improve renal function.