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胰岛素治疗口服降糖药失效的2型糖尿病的临床观察

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摘要 目的:探讨继发性口服降糖药物失效的2型糖尿病(T2DM)患者,应用预混人胰岛素类似物替代口服促胰岛素分泌类药物,配合二甲双胍或(和)α-糖苷酶抑制剂,对T2DM及其并发症的控制效果。方法:符合参与观察对象的T2DM患者50名,进行12周的随访,通过患者自身2种治疗方案前后血糖、血脂等指标的变化进行比较。结果:血糖、血压、糖化血红蛋白和甘油三酯下降,有显著性差异(P<0.01)。结论:对继发性口服降糖药物失效的T2DM患者,应用预混人胰岛素类似物替代口服促胰岛素分泌类药物,配合二甲双胍或(和)α-糖苷酶抑制剂,对T2DM患者血糖、血脂控制水平,提高血糖达标率有促进作用。
作者 东广玲
出处 《天津药学》 2013年第6期32-33,共2页 Tianjin Pharmacy
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  • 1European Diabetes Policy Group.A desktop guide to type 2 diabetes mellitus.Diabet Med,1999,16:716-730.
  • 2IDF.Clinical Guidelines Task Force.Global guideline for type 2 diabetes.Brussels:International Diabetes Federation,2005.http://www.idf.org/home/index.cfm?unode=B7462CCB-3A4C-472C-80E4-710074D74AD3(accessed August 2008).
  • 3Raskin P,Allen E,Hollander P,et al.Initiating insulin therapy in type 2 diabetes:a comparison of biphasic and basal insulin analogs.Diabetes Care,2005,28:260-265.
  • 4Kann PH,Wascher T,Zackova V,et al.Starting insulin therapy in type 2 diabetes:twice-daily biphasic insulin aspart 30 plus metformin versus once-daily insulin glargine plus glimepiride.Exp Clin Endocrinol Diabetes,2006,114:527-532.
  • 5Bebakar WMW,Chow CC,Kadir KA,et al.Adding biphasic insulin aspart 30 once or twice daily is more efficacious than optimizing oral antidiabetic treatment in patients with type 2 diabetes.Diabetes Obes Metab,2007,9:724-732.
  • 6Yang W,Ji Q,Zhu D,et al.Biphasic insulin aspart 30 three times daily is more effective than a twice-daily regimen without increasing hypoglycemia in Chinese subjects with type 2 diabetes inadequately controlled on oral antidiabetes drugs.Diabetes Care,2008,31:852-856.
  • 7Ligthelm RJ,Borz? V,Gumprecht J,et al.Importance of observational studies in clinical practice.Clin Ther,2007,29:1284-1292.
  • 8Khutsoane D,Sharma SK,Almustafa,M et al.Biphasic insulin aspart 30 treatment improves glycaemic control in patients with type 2 diabetes in a clinical practice setting:experience from the PRESENT study.Diabetes Obes Metab,2008,10:212-222.
  • 9Davies M.The reality of glycaemic control in insulin treated diabetes:defining the clinical challenges.Int J Obes,2004,28(Suppl.2):S14-22.
  • 10Peyrot M,Rubin RR,Lauritzen T,et al.Resistance to insulin therapy among patients and providers.Diabetes Care,2005,28:2673-2679.

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