普罗布考对早期老年2型糖尿病肾病的抗氧化作用

The anti-oxidation Effect of Probucol on the Old Patients with Elderly Type 2 Diabetic Nephropathy

目的评价普罗布考对老年2型糖尿病肾病抗氧化作用的疗效。方法 60例老年早期2型糖尿病肾病患者经伦理学委员会批准,并经患者知情同意分为2组,其中对照组(30例)给予饮食控制、降糖、降压,抗血小板聚集等常规治疗;治疗组(30例)在常规治疗基础上加服普罗布考0.5 g,2次/天,疗程12周;分别观察治疗前后两组患者空腹血糖(FBG)、肾功能、尿微量白蛋白排泄率(UAER)以及血清超氧化物歧化酶(SOD)和丙二醛(MDA)参数水平的变化。结果与治疗前比较,两组患者治疗后空腹血糖控制良好,差异均有显著性(P<0.05)。疗程结束后,与对照组比较,治疗组患者UAER明显下降(P<0.05),SOD较治疗前升高,MDA较治疗前明显下降,差异均具有显著性(P<0.05)。结论普罗布考改善早期老年糖尿病肾病患者的氧化应激状态,有效降低MDA水平,改善SOD活性,降低尿微量白蛋白,对早期糖尿病肾病具有保护作用。

Objective To evaluate the antioxidant efficacy of probucol in elderly type 2 diabetic nephropathy. Methods A randomized study was performed on 60 patients with early elderly type 2 diabetic nephropathy. The patients were randomly assigned to the control group （30 cases） which were given conventional treatment of diet, blood glucose, blood pressure, anti-platele aggregation, and treatment group （ 30 cases） on the basis of conventional therapy plus taking the probucol 0. 5 g,2 times/day, for 12 weeks;Fasting blood glucose （FBG）, renal function, urinary album in excretion rate （UAER）, Superoxide dismutase （SOD） and malondialdehyde（MDA） were measured at baseline and after 12 weeks. Resuits Compared with before the treatment,the indicators of blood glucose were decreased,with significant difference （P 〈 0.05 ）. After the treatment, the UAER was decreased significantly （ P 〈 0. 05 ）, concentration of the SOD levels were in- creased compared to the control group whereas the levels of MDA were lower than that group which didn＇ t use probucol, with significant difference （P 〈 0. 05 ）. Conclusion The treatment with probucol can improve oxidative stress in early elderly type 2 diabetic nephropathy, resulting in reduced serum MDA levels, improved SOD activity and decreased urinary albumin levels, thus contributing a greater protection effect on early diabetic nephropathy.