红花黄色素联合间歇性充气泵预防高龄直肠癌患者术后深静脉血栓形成的效果

Effect of Safflor Yellow Combined with Intermittent Pneumatic Pump on Prevention of Postoperative Deep Venous Thrombosis in Elderly Patients with Rectal Cancer

目的探讨红花黄色素联合间歇性充气泵预防高龄直肠癌患者(≥70岁)术后深静脉血栓形成的效果。方法选择2009年10月—2012年9月于河北医科大学第四医院确诊并接受手术治疗的高龄(≥70岁)直肠癌患者64例,按随机数字表法分为对照组25例,给予常规治疗;试验组39例,在常规治疗的基础上联合应用红花黄色素与间歇性充气泵预防深静脉血栓形成。比较两组患者深静脉血栓发生情况、血流动力学指标和各项凝血指标。结果两组患者均未出现深静脉血栓阳性症状和肺栓塞。试验组无症状深静脉血栓发生率低于对照组(5.1%与24.0%),差异有统计学意义(χ2=4.961,P=0.026)。试验组术后第8天峰速度、平均速度、单位时间血流量均较对照组升高,差异有统计学意义(P<0.05)。术后第8天试验组D-二聚体和纤维蛋白原水平低于对照组,凝血酶原时间和活化部分凝血活酶时间水平高于对照组,差异均有统计学意义(P<0.05)。结论红花黄色素联合间歇性充气泵预防高龄直肠癌患者术后深静脉血栓形成效果良好,建议临床推广应用。

Objective To observe the effect of combined application of safflor yellow and intermittent pneumatic pump on the prevention of postoperative deep venous thrombosis （DVT） in elderly patients with rectal cancer. Methods Totally 64 patients aged 70 years and above with rectal cancer receiving surgical therapy in Hebei Medical University Fourth Hospital between October 2009 and September 2012 were included in this study. They were randomly divide into treatment group （n = 39 ） and control group （ n = 25 ）. The treatment group were treated with safflor yellow combined with intermittent pneumatic pump, and the control group were treated with routine therapy. The incidence of DVT, indexes of hemodynamics and coagulation were tested in both groups. Results No symptomatic DVT and pulmonary embolism （PE） occurred in both groups. The incidence of a- symptomatic DVT was significantly lower in experimental group than in control group （5.13% vs. 24. 00% ; X2 =4. 961, P = 0. 026） ; the peak and mean blood flow velocities, and blood flow volume were significantly higher in the experimental group than in control group at 8th day postoperatively （P 〈 0. 05 ） ; the levels of D - dimer and Fibrinogen （Fib） in experimental group were significantly lower than those of in control group; and the prothrombin time （PT） and activated partial thromboplatin time （AP＇IT） in experimental group were significantly higher than those in control group （ all P 〈 0. 05 ）. Conclusion Combined application of safflor yellow and intermittent pneumatic pump is effective in preventing DVT in the elderly with rectal cancer after operation.