偏头痛湿热证与幽门螺杆菌感染的相关性研究

Relationship between Helicobacter Pylori Infection and Migraine with Damp-heat Syndrome

目的通过检测偏头痛湿热证病人幽门螺杆菌(HP)感染的阳性率,探讨幽门螺杆菌感染与偏头痛湿热证的相关关系。方法对偏头痛发作期病人60例和门诊健康体检者30名采用免疫印记检测血清HP抗体阳性率。其中根据中医证候诊断标准将病人分为湿热型组(31例)和非湿热型组(29例),同时检测三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、纤维蛋白原(FIB)水平。结果偏头痛病人的血清HP抗体阳性率明显高于健康对照组(65.0%vs26.7%,P<0.05)。偏头痛湿热组血清HP抗体阳性率、LDL-C水平均高于非湿热组(P<0.05);HDL-C、TC、TG、FIB与非湿热组相比差异无统计学意义(P>0.05)。偏头痛病人血清HP抗体阳性组的TG水平较血清HP抗体阴性组高(P<0.05);HDL-C、TC、LDL-C、FIB相比差异无统计学意义(P>0.05)。结论 HP感染与偏头痛湿热证关系密切,并可影响TG水平。HP感染可作为偏头痛湿热证的微观参考指标之一。

Objective To investigate the relationship between helicobacter pylori（HP） infection and migraine with damp - heat syndrome. Methods Sixty patients with attacks of migraine and thirty healthy individuals were analyzed. Serum antibody positive rate of HP was detected by immunoblot. According to traditional Chinese medieine（TCM） syndrome diagnostic criteria, patients were divided into damp - heat syndrome group （n=31） and nondamp - heat syndrome group （n 29）. Triglyceride （TG） ,total cholesterol （TC）, high density lipoprotein cholesterol （ HDL - C）, low density lipoprotein cholesterol （LDL - C）, fibrinogen （FIB） were detected. Results Serum antibody positive rate of HP in patients with attacks of migraine were higher than that in healthy individuals （P〈0.05）. Serum antibody positive rate of HP and LDL levels in damp - heat syndrome group were higher than that in non- damp - heat syndrome group （P〈0.05）. The levels of TG in serum HP antibody positive group were higher than that in serum HP antibody negative group （P〈0.05）. Conclusion HP infection was correlaed with migraine with dampheat syndrome, which could affect TG levels. HP infection might be one of the microscopic objective indexes for migraine with damp - heat syndrome.