左乙拉西坦治疗癫伴认知功能障碍患儿疗效观察

Effect of Levetiracetam on children with epilepsy and cognitive dysfunction

目的分析左乙拉西坦治疗癫伴认知功能障碍患儿的临床疗效。方法选择在本院接受治疗的癫伴认知功能障碍患儿作为研究对象,分别给予常规治疗及左乙拉西坦治疗,比较2组患儿的认知功能、脑电活动情况及生活质量评分等差异。结果观察组总有效率(66.67%)、MMES评分(25.47±4.83)、无认知功能障碍(83.33%)、躯体功能(76.87±7.16)、心理功能(59.32±5.34)、社会功能(58.76±2.16)、总体生活质量(82.34±8.21)评分均明显高于对照组(P<0.05);癫样放电(15%)、α波(18.21±3.36)、β波(10.32±2.25)、δ(12.36±2.25)、θ波(20.32±3.24)数目均明显少于对照组(P<0.05)。结论左乙拉西坦可有效改善癫伴认知功能障碍患儿的认知功能,减少异常脑电活动,提高生活质量。

Objective To analyze the effect of Levetiracetam on children with epilepsy and cognitive dysfunction. Methods Treatment in our hospital epilepsy children with cognitive dysfunction as research subjects was given conventional therapy and levetiracetam therapy. Children＇s cognitive function, EEG activity and quality of life score of two groups were compared. Results In observation group, the efficient （66.67%）, MMES （25.47±4.83）, no cognitive dysfunction （83.33%）, physical function（76.87±7.16）, psychological function （59.32±5.34）, social function （58.76±2.16）, the overall quality of life （82.34±8.21） were significantly higher than that of control group （P〈0.05） ± Epileptic discharge （15±±）, α（18.21 ± 3.36）,β （10.32±2.25）, δ（12. 36±2. 25）, θ（20.32±3.24） were significantly less than those in the control group （P〈0.05）. Conclusion Levetiracetam can be effective in improving cognitive function in children with epilepsy with cognitive function, and reduce abnormal EEG activity and improve the quality of life.