早期药物治疗对脑震荡患者伤后症状群的影响前瞻性研究

Prospective studies of early treatment for post cerebral concussion syndrome

目的探讨早期药物治疗应用于脑震荡患者伤后症候群的临床效果。方法选取我院收治的轻、中度脑震荡患者187例,随机分为3组,分别给予能量合剂、尼莫地平以及灯盏细辛静滴治疗,对比3组患者在治疗第7、21天时治疗效果;3个月后随访,对3组患者的复发情况进行统计分析。结果治疗7d、21d,灯盏细辛组有效率(87.50%、96.88%),明显高于尼莫地平(72.13%、80.33%)和能量合剂组(58.06%、61.29%);3个月随访结果显示,灯盏细辛组的伤后症候群发生率(4.69%)明显低于尼莫地平组(22.95%)和能量合剂组(38.71%,P<0.05)。结论在治疗早期选择有效对症药物对改善脑震荡初期症状以及抑制伤后症候群的发生有重要作用。

Objective To explore clinical efficacy of early treatment for post cerebral concussion syndrome. Methods Totally 187 cases of the patients with mild, moderate cerebral concussion in our hospital were selected and were divided into three groups randomly, treated with energy mixture, nimodipine and intravenous injection of erigeron breviscapus. Treatment effects of the three groups at 7d, 21d after the treatment were compared. After three months of follow-up, the recurrence of the three groups was analyzed. Results At 7d, 21d after the start of treatment, the treatment efficacy of erigeron breviscapus group （87.50%, 96.88%）, was significantly higher than them of nimodipine （72.13%, 80.33%） and energy mixture group （58.06 %, 61.29 %, P〈0.05）. At the following 3 months after injury, the ocurrence rate of post-concussion syndrome in the erigeron breviscapus group （4. 69%） was significantly lower than that of nimodipine group （22. 95%） and energy mixture group （38.71%, P〈0.05）. Conclusion It is important for improving initial symptoms and inhibitions of post-traumatic syn- drome to early select effective medicine on cerebral concussion symptoms