盐酸氟西汀联合认知行为疗法治疗产后抑郁症疗效观察

Efficacy of fluoxetine hydrochloride combined with cognitive behavior therapy for postpartum depression

目的探讨盐酸氟西汀联合认知行为疗法治疗产后抑郁症的临床疗效及不良反应。方法入组103例产后抑郁症患者分为2组,联合治疗组53例接受盐酸氟西汀联合认知行为疗法,对照组50例仅接受盐酸氟西汀治疗。2组均治疗6周。然后采用汉密尔顿抑郁量表(HAMD)评价治疗效果,同时采用不良反应量表(TESS)评价盐酸氟西汀的不良反应。结果联合治疗组总有效率84.9%,远高于对照组68.0%(P<0.05)。联合治疗组治疗后HAMD评分低于对照组(P<0.05)。2组药物不良反应比较差异无统计学意义(P>0.05)。结论盐酸氟西汀联合认知行为疗法治疗产后抑郁症的临床疗效优于单用盐酸氟西汀,而不良反应并未增加。

Objective To evaluate the clinical efficacy and toxicities of fluoxetine hydrochloride combined with cognitive behavior therapy for postpartum depression. Methods Totally 103 patients with postpartum depression were divided into 2 group, 53 patients of the combined treatment group received the fluoxetine hydrochloride and cognitive behavior therapy, while 50 patients of the control group only received fluoxetine. The Hamilton depression rating scale （HAMD） was used to evaluate clinical efficacy, and treatment emergent symptom scale （TESS） was used to evaluate fluoxetine toxicities. Results The total effective rate in the combined treatment group （84.9%） was significantly higher than that in the control group （68.0%, P〈0. 05）. After the treatment, the HAMD score of the combined treatment group was lower than that in the control group （P〈0. 05）. There was no significant difference in the toxicities between the two groups （P〉0. 05）. Conclusion The efficacy of fluox etine hydroehloride combined with cognitive behavior therapy is belier than only fluoxetine hydrochloride for postpartum depression and the toxicities is similar to the fluoxetine hydroehloride.