艾司西酞普兰与帕罗西汀治疗老年抑郁症对比分析

Comparative study of escitalopram and paroxetine on the elderly patients with depression

目的探讨艾司西酞普兰与帕罗西汀治疗老年抑郁症患者的临床效果。方法选取2012-01—2012-12我院收治的老年抑郁症患者88例,随机分为艾司西酞普兰组和帕罗西汀组,每组44例。艾司西酞普兰组采用草酸艾司西酞普兰片治疗,帕罗西汀组采用盐酸帕罗西汀片治疗,比较2组患者的临床疗效和并发症发生情况。结果艾司西酞普兰组痊愈率和总有效率分别为52.27%、93.18%,均明显高于帕罗西汀组的36.36%、77.27%,差异均具有统计学意义(P<0.05);艾司西酞普兰组口干、恶心、头痛、出汗、便秘等不良反应发生率较帕罗西汀组均呈不同程度降低,但差异均无统计学意义(P>0.05)。结论艾司西酞普兰治疗老年抑郁症,其疗效确切,效果显著,安全性高,是老年抑郁症患者较为理想的临床治疗药物。

Objective To explore the clinical effect of escitalopram and paroxetine on elderly patients with depres sion. Methods Totally 88 elderly patients with depression in our hospital from January 2012 to December 2012 were selected and were divided into escitalopram group and paroxetine group randomly. There were 44 cases in each group. The escitalopram group was treated with escitalopram oxalate tablets. The paroxetine group was treated with paroxetine hydrochloride. The clinical treatment and complications of the patients in two groups were compared and analyzed. Results The curative rate and total effective rate of escitalopram group （52.57% and 93.18%） were significantly higher than them of paroxetine group （36.36 and 77.27%, P〈0.05）. Compared with paroxeline group, the incidences of adverse reactions including dry mouth, nausea, headache, sweating and constipation of the escitalopram group were lower, but there were no significant differences （P 〉0.05）. Conclusion Eseitalopram is significantly efficacious and safe in the treatment of elderly patients with depression. It is the ideal clinical treatment drugs for them.