糖尿病周围神经病变患者微循环状态变化研究

Study on the change of microcirculation state of patients with diabetic peripheral neurophathy

目的研究糖尿病周围神经病变患者微循环状态的变化。方法选取2012-02—2013-05于本院进行治疗的65例糖尿病周围神经病变患者为观察组,并以同期体检的健康同龄人65例为对照组,比较2组甲襞微循环与不同切度全血黏度、血浆黏度指标,观察组中不同分期患者的检测结果。结果观察组甲襞微循环与不同切度全血黏度、血浆黏度指标均低于对照组,且3期患者高于1期与2期患者,2期患者则高于1期患者,差异均有统计学意义(P<0.05)。结论糖尿病周围神经病变患者微循环状态相对较差,且分期越高者检测水平越差,因此可用于了解患者的疾病状况。

Objective To study and analyze the change of microcirculation state of patients with diabetic peripheral neuropathy. Methods Totally 65 patients with diabetic peripheral neuropathy in our hospital from February 2012 to May 2013 were selected as observation group, the nailfold microcirculation and whole blood viscosity indexes at different shear rate of two groups were compared,and the detection results of observation group with different stages were compared too. Results The nailfold microcirculation and whole blood viscosity indexes at different shear rate, plasma viscosity, plasma viscosity o~ observa- tion group were all worse than those of control group,and the detection results of observation group at stage 3 were worse than those of patients at stage 1 and stage 2 ,those of patients at stage 2 were worse than those at stage 1（all P〈0.05）. Conclusion The microcirculation state of patients with diabetic peripheral neuropathy is respectively worse,and the higher the stage, the worse the detection levels,so it can be as the index of understanding the disease situation of patients.