依达拉奉对急性脑梗死患者神经功能状态的影响

The influence of edaravone on the neurological status of patients with acute cerebral infarction

目的观察依达拉奉对急性脑梗死患者神经功能状态的改善作用。方法将本院2011-01—2013-02收治的急性脑梗死患者随机分成对照组和观察组各84例。对照组采用胞磷胆碱治疗,观察组采用依达拉奉治疗。治疗前、治疗后2周及1个月后,分别采用美国国立卫生研究院卒中量表(NIHSS)及Barthel指数对2组患者的神经功能状态进行评分。结果治疗后2周及1个月结果显示,观察组NIHSS评分均显著低于对照组,而Barthel指数则显著高于对照组(P<0.05)。观察组显效率显著高于对照组(P<0.05)。结论依达拉奉能有效改善急性脑梗死患者的神经功能缺失及生活能力缺陷,疗效优于胞磷胆碱。

] Objective To investigate the influence of edaravone on the neurological status of patients with acute cerebral infarction. Methods Totally 168 cases with acute cerebral infarction from January 2011 to February 2012 were randomly divid- ed into control group（citicoline treatment group）with 84 cases and observation group（edaravone treatment group）with 84cases, then the NIHSS score,Barthel index before the treatment and at 2nd week after the treatment of two groups were compared. Results After 2 weeks of treatment and one month followingup,the NIHSS score of observation group were significantly lower than that of control group,and the Barthel index of observation group were significantly higher than those that of control group, and the efficiency of observation group was significantly higher than that of control group, all P〈0.05. Conclusion Edaravone can effectively improve the neurological deficits and daily life skills deficiencies of patients with acute cerebral infarction, and is superior to citicoline.